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UniProtKB/Swiss-Prot entry Q00583

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH3_HEVBR
Primary accession number Q00583
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 60)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3
Synonyms HMG-CoA reductase 3
EC 1.1.1.34
Gene name
Name: HMGR3
From
Hevea brasiliensis (Para rubber tree) [TaxID: 3981] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids I; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae; Hevea.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1007/BF00023395; PubMed=1377968 [NCBI, ExPASy, EBI, Israel, Japan]
Chye M.L., Tan C.T., Chua N.H.;
"Three genes encode 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hevea brasiliensis: hmg1 and hmg3 are differentially expressed.";
Plant Mol. Biol. 19:473-484(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M74800; AAA33360.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M74798; AAA33358.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M74799; AAA33359.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S22521; S22521.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q00583.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0042170; Cellular component: plastid membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q00583.
Other
ProtoNet Q00583.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; Mitochondrion; NADP; Oxidoreductase; Plastid; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   586  586     3-hydroxy-3-methylglutaryl-coenzyme A reductase 3. PRO_0000114442
TRANSMEM   36    59  24     By similarity. 
TRANSMEM   87   107  21     By similarity. 
REGION   108   170  63     Linker (By similarity). 
REGION   171   586  416     Catalytic (By similarity). 
REGION   172   586  415     Catalytic (By similarity). 
ACT_SITE   265   265        Charge relay system (By similarity). 
ACT_SITE   397   397        Charge relay system (By similarity). 
ACT_SITE   473   473        Charge relay system (By similarity). 
ACT_SITE   571   571        Proton donor (By similarity). 
CARBOHYD   575   575        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 586 AA [This is the length of the unprocessed precursor] Molecular weight: 62970 Da [This is the MW of the unprocessed precursor] CRC64: 0B9D6DCC5979B456 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDEVRRRPPK HIVRKDHDGE VLNSFSHGHH LPPLKPSDYS LPLSLYLANA LVFSLFFSVA 

        70         80         90        100        110        120 
YFLLHRWREK IRKSTPLHIV TFPEIAALIC LVASVIYLLG FFGIGFVHSF SRASTDSWDV 

       130        140        150        160        170        180 
EEYDDDNIII KEDTRPTGAC AAPSLDCSLS LPTKIHAPIV STTTTSTLSD DDEQIIKSVV 

       190        200        210        220        230        240 
SGSIPSYSLE SKLGNCKRAA LIRRETLQRM SGRSLEGLPL DGFDYESILG QCCEMAIGYV 

       250        260        270        280        290        300 
QIPVGIAGPL LLDGKEYTVP MATTEGCLVA SANRGCKAIY ASGGATSVLL RDGMTRAPVV 

       310        320        330        340        350        360 
RFPTAKRAAD LKFFMEDPDN FDTIAVVFNK SSRFARLQSV QCAIAGKNLY MRFSCSTGDA 

       370        380        390        400        410        420 
MGMNMVSKAV QNVIDYLQND FPDMDVIGLT GNFCADKKAA AVNWIEGRGK SVVCEAIIKE 

       430        440        450        460        470        480 
EVVKKVLKTN VAALVELNMI KNLTGSAVAG SLGGFNAHAS NMVTAVYIAT GQDPAQNVES 

       490        500        510        520        530        540 
SHCITMMEAV NDGKDLHISV SMPSIELGTV GGGTQLASQS ACLNLLGVKG ASKDSPGSNS 

       550        560        570        580 
RLLATIVAGS VLAGELSLMS AIAAGQLVNS HMKYNRSAKD VSKITF
Q00583 in FASTA format

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View entry in raw text format (no links)
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