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UniProtKB/Swiss-Prot entry Q00415


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_COCPO
Primary accession number Q00415
Secondary accession numbers Q02288 Q400Q0 Q400Q8 Q9C0M8
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms HPPDase
4HPPD
HPD
EC 1.13.11.27
T-cell reactive protein
Gene name
Name: TCRP
From
Coccidioides posadasii [TaxID: 199306] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C735;
DOI=10.1016/0378-1119(95)00250-A; PubMed=7642122 [NCBI, ExPASy, EBI, Israel, Japan]
Wyckoff E.E., Pishko E.J., Kirkland T.N., Cole G.T.;
"Cloning and expression of a gene encoding a T-cell reactive protein from Coccidioides immitis: homology to 4-hydroxyphenylpyruvate dioxygenase and the mammalian F antigen.";
Gene 161:107-111(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-362.
STRAIN=RMSCC 757 / Silveira;
DOI=10.1073/pnas.94.10.5478; PubMed=9144263 [NCBI, ExPASy, EBI, Israel, Japan]
Koufopanou V., Burt A., Taylor J.W.;
"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis.";
Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997).
[3]
ERRATUM.
Koufopanou V., Burt A., Taylor J.W.;
Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-383, AND VARIANT SER-250.
STRAIN=IFM 45809, IFM 45810, IFM 45811, IFM 45812, IFM 45813, IFM 45817, IFM 4935, IFM 4945, IFM 50993, IFM 50994, IFM 51112, IFM 54194, IFM 54195, and IFM 54196;
PubMed=16699492 [NCBI, ExPASy, EBI, Israel, Japan]
Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K.;
"Reexamination of Coccidioides spp. reserved in the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a multiple gene analysis.";
Nippon Ishinkin Gakkai Zasshi 47:113-117(2006).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 237-305.
STRAIN=C634, and C735;
PubMed=1840578 [NCBI, ExPASy, EBI, Israel, Japan]
Kirkland T.N., Zhu S., Kruse D., Hsu L., Seshan K.R., Cole G.T.;
"Coccidioides immitis fractions which are antigenic for immune T lymphocytes.";
Infect. Immun. 59:3952-3961(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L38493; AAA82574.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ291968; CAC35132.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232864; BAE20309.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232865; BAE20310.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232866; BAE20311.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232867; BAE20312.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232868; BAE20313.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232869; BAE20314.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232870; BAE20315.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232873; BAE20318.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232876; BAE20321.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232877; BAE20322.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232879; BAE20324.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232880; BAE20325.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232881; BAE20326.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB232882; BAE20327.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S69110; AAC60567.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P80064; 1CJX. [HSSP ENTRY / PDB]
ModBase Q00415.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q00415.
Other
ProtoNet Q00415.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   399  399     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088403
METAL   200   200        Iron (By similarity). 
METAL   283   283        Iron (By similarity). 
METAL   366   366        Iron (By similarity). 
VARIANT   250   250  1     N -> S (in strain: IFM 45817). 
CONFLICT   297   297        N -> T (in Ref. 5; AAC60567). 
Sequence information
Length: 399 AA [This is the length of the unprocessed precursor] Molecular weight: 45262 Da [This is the MW of the unprocessed precursor] CRC64: 342DEFF33091C3C2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAPAADSPTL QPAQPSDLNQ YRGYDHVHWY VGNAKQAATY YVTRMGFERV AYRGLETGSK 

        70         80         90        100        110        120 
AVASHVVRNG NITFILTSPL RSVEQASRFP EDEALLKEIH AHLERHGDGV KDVAFEVDCV 

       130        140        150        160        170        180 
ESVFSAAVRN GAEVVSDVRT VEDEDGQIKM ATIRTYGETT HTLIERSGYR GGFMPGYRME 

       190        200        210        220        230        240 
SNADATSKFL PKVVLERIDH CVGNQDWDEM ERVCDYYEKI LGFHRFWSVD DKDICTEFSA 

       250        260        270        280        290        300 
LKSIVMASPN DIVKMPINEP AKGKKQSQIE EYVDFYNGAG VQHIALRTNN IIDAITNLKA 

       310        320        330        340        350        360 
RGTEFIKVPE TYYEDMKIRL KRQGLVLDED FETLKSLDIL IDFDENGYLL QLFTKHLMDR 

       370        380        390 
PTVFIEIIQR NNFSGFGAGN FRALFEAIER EQALRGTLI 

Q00415 in FASTA format

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