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UniProtKB/Swiss-Prot entry P99074


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AHPC_STAAN
Primary accession number P99074
Secondary accession number Q53647
Integrated into Swiss-Prot on March 1, 2005
Sequence was last modified on March 1, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 22)
Name and origin of the protein
Protein name Alkyl hydroperoxide reductase subunit C
Synonyms EC 1.11.1.15
Peroxiredoxin
Thioredoxin peroxidase
Gene name
Name: ahpC
OrderedLocusNames: SA0366
From
Staphylococcus aureus (strain N315) [TaxID: 158879] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(00)04403-2; PubMed=11418146 [NCBI, ExPASy, EBI, Israel, Japan]
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y., Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.;
"Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
Lancet 357:1225-1240(2001).
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
DOI=10.1016/j.mimet.2004.09.017; PubMed=15590099 [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Francois P., Bento M., Deshusses J.M., Charbonnier Y., Converset V., Huyghe A., Walter N., Hoogland C., Appel R.D., Sanchez J.-C., Zimmermann-Ivol C.G., Corthals G.L., Hochstrasser D.F., Schrenzel J.;
"Correlation of proteomic and transcriptomic profiles of Staphylococcus aureus during the post-exponential phase of growth.";
J. Microbiol. Methods 60:247-257(2005).
[3]
IDENTIFICATION BY MASS SPECTROMETRY.
Vaezzadeh A.R., Deshusses J., Lescuye P., Hochstrasser D.F.;
"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315.";
Submitted (OCT-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000018; BAB41593.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F89804; F89804.
RefSeq NP_373615.1; -.
3D structure databases
HSSP P19479; 1N8J. [HSSP ENTRY / PDB]
ModBase P99074.
Enzyme and pathway databases
BioCyc SAUR158879:SA0366-MON; -.
2D gel databases
SWISS-2DPAGE P99074; -.
Family and domain databases
InterPro IPR000866; AhpC-TSA.
IPR017559; Peroxiredoxin.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1.
Pfam PF00578; AhpC-TSA; 1.
Pfam graphical view of domain structure.
PROSITE PS51352; THIOREDOXIN_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P99074.
Genome annotation databases
GeneID 1123148; -.
GenomeReviews BA000018_GR; SA0366.
KEGG sau:SA0366; -.
Phylogenomic databases
HOGENOM P99074; -.
Genome annotation databases
CMR P99074; SA0366.
Other
ProtoNet P99074.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antioxidant; Complete proteome; Oxidoreductase; Peroxidase; Redox-active center.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   189  189     Alkyl hydroperoxide reductase subunit C. PRO_0000135124
DOMAIN   2   159  158     Thioredoxin. 
ACT_SITE   49    49        Cysteine sulfenic acid (-SOH) intermediate (By similarity). 
DISULFID   49    49        Interchain (with C-168); in linked form (By similarity). 
DISULFID   168   168        Interchain (with C-49); in linked form (By similarity). 
Sequence information
Length: 189 AA [This is the length of the unprocessed precursor] Molecular weight: 20977 Da [This is the MW of the unprocessed precursor] CRC64: B7134A9C84066B73 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLINKEILP FTAQAFDPKK DQFKEVTQED LKGSWSVVCF YPADFSFVCP TELEDLQNQY 

        70         80         90        100        110        120 
EELQKLGVNV FSVSTDTHFV HKAWHDHSDA ISKITYTMIG DPSQTITRNF DVLDEATGLA 

       130        140        150        160        170        180 
QRGTFIIDPD GVVQASEINA DGIGRDASTL AHKIKAAQYV RKNPGEVCPA KWEEGAKTLQ 


PGLDLVGKI 

P99074 in FASTA format

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