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UniProtKB/Swiss-Prot entry P97837

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DLGP2_RAT
Primary accession number P97837
Secondary accession numbers None
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on July 19, 2005 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Disks large-associated protein 2
Synonyms DAP-2
SAP90/PSD-95-associated protein 2
SAPAP2
PSD-95/SAP90-binding protein 2
Gene name
Name: Dlgap2
Synonyms: Dap2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION WITH DLG4.
TISSUE=Brain;
DOI=10.1074/jbc.272.18.11943; PubMed=9115257 [NCBI, ExPASy, EBI, Israel, Japan]
Takeuchi M., Hata Y., Hirao K., Toyoda A., Irie M., Takai Y.;
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.";
J. Biol. Chem. 272:11943-11951(1997).
[2]
 PROTEIN SEQUENCE OF 234-241 AND 710-715, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Brain;
Lubec G., Kang S.U., Lubec S.;
Submitted (SEP-2007) to UniProtKB.
[3]
 TISSUE SPECIFICITY.
DOI=10.1016/j.molbrainres.2004.03.014; PubMed=15207911 [NCBI, ExPASy, EBI, Israel, Japan]
Kindler S., Rehbein M., Classen B., Richter D., Boeckers T.M.;
"Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA.";
Brain Res. Mol. Brain Res. 126:14-21(2004).
Comments
  • FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
  • SUBUNIT: Interacts with DLG4/PSD-95.
  • INTERACTION:
    P31016:Dlg4; NbExp=1; IntAct=EBI-81025, EBI-375655;
  • SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells.
  • TISSUE SPECIFICITY: Expressed in various brain areas.
  • SIMILARITY: Belongs to the SAPAP family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U67138; AAB48588.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446353.1; -.
UniGene Rn.10705
3D structure databases
ModBase P97837.
Protein-protein interaction databases
IntAct P97837; -.
PTM databases
PhosphoSite P97837; -.
Organism-specific databases
RGD 620224; Dlgap2.
Gene expression databases
ArrayExpress P97837; -.
GermOnline ENSRNOG00000012573; Rattus norvegicus.
Ontologies
GO
GO:0005883; Cellular component: neurofilament (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (non-traceable author statement from UniProtKB).
GO:0007270; Biological process: nerve-nerve synaptic transmission (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR005026; GKAP.
Graphical view of domain structure.
Pfam PF03359; GKAP; 1.
Pfam graphical view of domain structure.
BLOCKS P97837.
Genome annotation databases
Ensembl ENSRNOG00000012573; Rattus norvegicus. [Contig view]
GeneID 116681; -.
KEGG rno:116681; -.
Phylogenomic databases
HOVERGEN P97837; -.
Other
ProtoNet P97837.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Direct protein sequencing; Membrane; Phosphoprotein; Postsynaptic cell membrane; Synapse.
Features
SEVIEWER logo Feature table viewer
KeyFrom    To Length Description FTId
CHAIN   1   1059  1059     Disks large-associated protein 2. PRO_0000174293
MOD_RES   228    228        Phosphoserine (By similarity). 
MOD_RES   312    312        Phosphotyrosine (By similarity). 
MOD_RES   440    440        Phosphoserine (By similarity). 
MOD_RES   450    450        Phosphoserine (By similarity). 
MOD_RES   453    453        Phosphoserine (By similarity). 
MOD_RES   574    574        Phosphoserine (By similarity). 
MOD_RES   745    745        Phosphoserine (By similarity). 
MOD_RES   1012   1012        Phosphoserine (By similarity). 
MOD_RES   1040   1040        Phosphoserine (By similarity). 
MOD_RES   1047   1047        Phosphoserine (By similarity). 
Sequence information
Length: 1059 AA [This is the length of the unprocessed precursor] Molecular weight: 118978 Da [This is the MW of the unprocessed precursor] CRC64: 8AB2A3667AD79434 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEGGD LAQPGLSFPG PAEEDIDQQY 

        70         80         90        100        110        120 
SWSPTQHFSE ERYSPAPRNM KGLTGSRNQP QLCVGHTCGL SPTDECEHPH DHVRHGPDVR 

       130        140        150        160        170        180 
QPYLLSPAES CPMDHHRCSP RSSVHSECMM MPVMLGDHVS SSTFPRMHYS SHYDTRDDCA 

       190        200        210        220        230        240 
TSHASTKVNR IPANLLDQFE KQLPLHRDGF HTLQYHRASA ATEQRNESPG RIRHLVHSVQ 

       250        260        270        280        290        300 
KLFTKSHSLE GSSKSNINGT KSEGRMDDHH QSHLSKHSKR SKSKERKPES KHKSGMSSWW 

       310        320        330        340        350        360 
SSDDNLDSDS TYRTPSVAHR HHMDHIPHCY PEALQSPFGD LSLKTSKSNS DVKCSACEGL 

       370        380        390        400        410        420 
ALTPDTRYMK RSSWSTLTVS QAKEAYRKSS LNLDKPLVHP EIKPSLQPCH YLQVPQDDWG 

       430        440        450        460        470        480 
AYPTGGKEEE IPCRRMRSGS YIKAMGDEES GESDSSPKTS PTVALRPEPL LKSIIQRPLG 

       490        500        510        520        530        540 
DHQTQSYLQA ATEVPVGHSL DPSVNYNSPK FRSRNQSYMR AVSTLSQASC VSQMSEAEVN 

       550        560        570        580        590        600 
GQFESVCESV FSEVESQAMD ALDLPGCFRT RSHSYLRAIQ AGYSQDDECI PVMTPSNMTS 

       610        620        630        640        650        660 
TIRSTAAVSY TNYKKTPPPV PPRTTSKPLI SVTAQSSTES TQDAYQDSRA QRMSPWPQDS 

       670        680        690        700        710        720 
RGGLYNSMDS LDSNKAMNLA LESAAAQRHA ADTQSSSTRS IDKAVLVSKA EELLKSRCSS 

       730        740        750        760        770        780 
IGVQDSEFPD HQPYPRSDVE TATDSDTESR GLREYHSVGV QVEDEKRHGR FKRSNSVTAA 

       790        800        810        820        830        840 
VQADLELEGF PGHVSMEDKG LQFGSSFQRH SEPSTPTQYG ALRTVRTQGL FSYREDYRTQ 

       850        860        870        880        890        900 
VDTSTLPPPD PWLEPSLDTV ETGRMSPCRR DGSWFLKLLH TETKKMEGWC KEMEREAEEN 

       910        920        930        940        950        960 
DLSEEILGKI RSAVGSAQLL MSQKFQQFYW LCQQNMDPSA MPRPTSQDLA GYWDMLQLSV 

       970        980        990       1000       1010       1020 
EDVSMKFDEL HQLKLNDWKI MESPERKEER KIPPPIPKKP PKGKFPITRE KSLDLPDRQR 

      1030       1040       1050 
QEARRRLMAA KRAASFRQNS ATERADSIEI YIPEAQTRL
P97837 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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