[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), AND INTERACTION WITH DLG1; DLG2; DLG3 AND DLG4.
TISSUE=Brain;
DOI=10.1083/jcb.136.3.669; PubMed=9024696 [NCBI, ExPASy, EBI, Israel, Japan]
Kim E.,
Naisbitt S.,
Hsueh Y.-P.,
Rao A.,
Rothschild A.,
Craig A.M.,
Sheng M.;
"GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.";
J. Cell Biol. 136:669-678(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 5 AND 6), AND DEVELOPMENTAL STAGE.
DOI=10.1016/S0014-5793(97)01399-9; PubMed=9428732 [NCBI, ExPASy, EBI, Israel, Japan]
Kawashima N.,
Takamiya K.,
Sun J.,
Kitabatake A.,
Sobue K.;
"Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development.";
FEBS Lett. 418:301-304(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1074/jbc.272.18.11943; PubMed=9115257 [NCBI, ExPASy, EBI, Israel, Japan]
Takeuchi M.,
Hata Y.,
Hirao K.,
Toyoda A.,
Irie M.,
Takai Y.;
"SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.";
J. Biol. Chem. 272:11943-11951(1997).
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[4]
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INTERACTION WITH BEGAIN AND DLG4.
DOI=10.1074/jbc.273.41.26269; PubMed=9756850 [NCBI, ExPASy, EBI, Israel, Japan]
Deguchi M.,
Hata Y.,
Takeuchi M.,
Ide N.,
Hirao K.,
Yao I.,
Irie M.,
Toyoda A.,
Takai Y.;
"BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein.";
J. Biol. Chem. 273:26269-26272(1998).
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[5]
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INTERACTION WITH DLG4 AND SHANK PROTEINS.
DOI=10.1006/bbrc.1999.1489; PubMed=10527873 [NCBI, ExPASy, EBI, Israel, Japan]
Boeckers T.M.,
Winter C.,
Smalla K.-H.,
Kreutz M.R.,
Bockmann J.,
Seidenbecher C.,
Garner C.C.,
Gundelfinger E.D.;
"Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.";
Biochem. Biophys. Res. Commun. 264:247-252(1999).
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[6]
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INTERACTION WITH DLG4 AND SHANK1.
TISSUE=Brain;
DOI=10.1074/jbc.274.39.27463; PubMed=10488079 [NCBI, ExPASy, EBI, Israel, Japan]
Yao I.,
Hata Y.,
Hirao K.,
Deguchi M.,
Ide N.,
Takeuchi M.,
Takai Y.;
"Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein.";
J. Biol. Chem. 274:27463-27466(1999).
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[7]
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INTERACTION WITH SHANK PROTEINS, AND MUTAGENESIS OF THR-990; ARG-991 AND LEU-992.
DOI=10.1016/S0896-6273(00)80809-0; PubMed=10433268 [NCBI, ExPASy, EBI, Israel, Japan]
Naisbitt S.,
Kim E.,
Tu J.C.,
Xiao B.,
Sala C.,
Valtschanoff J.,
Weinberg R.J.,
Worley P.F.,
Sheng M.;
"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.";
Neuron 23:569-582(1999).
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[8]
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INTERACTION WITH AIP1.
DOI=10.1074/jbc.273.33.21105; PubMed=9694864 [NCBI, ExPASy, EBI, Israel, Japan]
Hirao K.,
Hata Y.,
Ide N.,
Takeuchi M.,
Irie M.,
Yao I.,
Deguchi M.,
Toyoda A.,
Suedhof T.C.,
Takai Y.;
"A novel multiple PDZ domain-containing molecule interacting with N-methyl-d-aspartate receptors and neuronal cell adhesion proteins.";
J. Biol. Chem. 273:21105-21110(1998).
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[9]
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INTERACTION WITH DYL2.
DOI=10.1002/pmic.200300528; PubMed=14760703 [NCBI, ExPASy, EBI, Israel, Japan]
Navarro-Lerida I.,
Martinez Moreno M.,
Roncal F.,
Gavilanes F.,
Albar J.P.,
Rodriguez-Crespo I.;
"Proteomic identification of brain proteins that interact with dynein light chain LC8.";
Proteomics 4:339-346(2004).
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[10]
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INTERACTION WITH LRFN1.
DOI=10.1016/j.neuron.2006.04.005; PubMed=16630835 [NCBI, ExPASy, EBI, Israel, Japan]
Ko J.,
Kim S.,
Chung H.S.,
Kim K.,
Han K.,
Kim H.,
Jun H.,
Kaang B.-K.,
Kim E.;
"SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.";
Neuron 50:233-245(2006).
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- FUNCTION: Part of the postsynaptic scaffold in neuronal cells.
- SUBUNIT: Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1.
- INTERACTION:
P31016:Dlg4; NbExp=3; IntAct=EBI-80901, EBI-375655;
P97879:Grip1; NbExp=1; IntAct=EBI-80901, EBI-936113;
Q9WV48:Shank1; NbExp=3; IntAct=EBI-80901, EBI-80909;
- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Found in postsynaptic density of neuronal cells.
- ALTERNATIVE PRODUCTS:
6 named isoforms [FASTA] produced by alternative splicing.
- TISSUE SPECIFICITY: Expressed in brain and testis.
- DEVELOPMENTAL STAGE: Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development.
- SIMILARITY: Belongs to the SAPAP family.
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