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UniProtKB/Swiss-Prot entry P97501

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO3_MOUSE
Primary accession number P97501
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 3
Synonyms EC 1.14.13.8
Hepatic flavin-containing monooxygenase 3
FMO 3
Dimethylaniline oxidase 3
Gene name
Name: Fmo3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=CD-1;
TISSUE=Liver;
DOI=10.1006/abbi.1997.0322; PubMed=9344459 [NCBI, ExPASy, EBI, Israel, Japan]
Falls J.G., Cherrington N.J., Clements K.M., Philpot R.M., Levi P.E., Rose R.L., Hodgson E.;
"Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform.";
Arch. Biochem. Biophys. 347:9-18(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U87147; AAB47541.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_032056.1; -.
UniGene Mm.2900
3D structure databases
ModBase P97501.
Organism-specific databases
MGI MGI:1100496; Fmo3.
Gene expression databases
ArrayExpress P97501; -.
CleanEx MM_FMO3; -.
GermOnline ENSMUSG00000026691; Mus musculus.
Family and domain databases
InterPro IPR000759; Adrndx_reductase.
IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002255; Flavin_mOase_3.
IPR001100; Pyr_nuc-diS_OxRdtase.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01123; FMOXYGENASE3.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P97501.
Genome annotation databases
Ensembl ENSMUSG00000026691; Mus musculus. [Contig view]
GeneID 14262; -.
KEGG mmu:14262; -.
Phylogenomic databases
HOGENOM P97501; -.
HOVERGEN P97501; -.
Other
SOURCE Fmo3; Mus musculus.
ProtoNet P97501.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   534  534     Dimethylaniline monooxygenase [N-oxide-forming] 3. PRO_0000147656
NP_BIND   9    14  6     FAD (Potential). 
NP_BIND   191   196  6     NADP (Potential). 
Sequence information
Length: 534 AA [This is the length of the unprocessed precursor] Molecular weight: 60516 Da [This is the MW of the unprocessed precursor] CRC64: F72F7993C01AF9C9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKKVAIIGA GVSGLAAIRS CLEEGLEPTC FERSDDVGGL WKFSDHIEEG RASIYQSVFT 

        70         80         90        100        110        120 
NSSKEMMCFP DFPYPDDFPN FMHHSKLQEY ITSFAKEKNL LKYIQFETPV TSINKCPNFS 

       130        140        150        160        170        180 
TTGKWEVTTE KHGKKETAVF DATMICSGHH IFPHVPKDSF PGLNRFKGKC FHSRDYKEPG 

       190        200        210        220        230        240 
IWKGKRVLVI GLGNSGCDIA AELSHVAQKV TISSRSGSWV MSRVWDDGYP WDMVVLTRFQ 

       250        260        270        280        290        300 
TFLKNNLPTA ISDWWYTRQM NARFKHENYG LVPLNRTLRK EPVFNDELPA RILCGMVTIK 

       310        320        330        340        350        360 
PNVKEFTETS AVFEDGTMFE AIDCVIFATG YGYAYPFLDD SIIKSRNNEV TLYKGVFPPQ 

       370        380        390        400        410        420 
LEKPTMAVIG LVQSLGATIP ITDLQARWAA QVIKGTCTLP SVNDMMDDID EKMGEKFKWY 

       430        440        450        460        470        480 
GNSTTIQTDY IVYMDELASF IGAKPNLLWL FLKDPRLAVE VFFGPCSPYQ FRLVGPGKWS 

       490        500        510        520        530 
GARNAILTQW DRSLKPMKTR VVSKVQKSCS HFYSRLLRLL AVPVLLIALF LVLI
P97501 in FASTA format

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