ID   G6PD2_MOUSE             Reviewed;         513 AA.
AC   P97324;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-NOV-2008, entry version 76.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase 2;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=G6pd2; Synonyms=G6pd-2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Swiss;
RX   MEDLINE=97312691; PubMed=9169132; DOI=10.1006/geno.1997.4673;
RA   Hendriksen P.J.M., Hoogerbrugge J.W., Baarends W.M., de Boer P.,
RA   Vreeburg J.T.M., Vos E.A., van der Lende T., Grootegoed A.J.;
RT   "Testis-specific expression of a functional retroposon encoding
RT   glucose-6-phosphate dehydrogenase in the mouse.";
RL   Genomics 41:350-359(1997).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- MISCELLANEOUS: Has NADP both as cofactor (bound to the N-terminal
CC       domain) and as structural element bound to the C-terminal domain.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; Z84471; CAB06476.1; -; Genomic_DNA.
DR   RefSeq; NP_062341.1; -.
DR   UniGene; Mm.347430; -.
DR   HSSP; P11413; 1QKI.
DR   SMR; P97324; 28-513.
DR   PhosphoSite; P97324; -.
DR   Ensembl; ENSMUSG00000031400; Mus musculus.
DR   GeneID; 14380; -.
DR   KEGG; mmu:14380; -.
DR   MGI; MGI:105977; G6pd2.
DR   HOGENOM; P97324; -.
DR   HOVERGEN; P97324; -.
DR   NextBio; 285889; -.
DR   ArrayExpress; P97324; -.
DR   CleanEx; MM_G6PD2; -.
DR   GermOnline; ENSMUSG00000045120; Mus musculus.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Carbohydrate metabolism; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    513       Glucose-6-phosphate 1-dehydrogenase 2.
FT                                /FTId=PRO_0000068086.
FT   ACT_SITE    263    263       Proton acceptor (By similarity).
FT   BINDING      40     40       NADP (By similarity).
FT   BINDING      72     72       NADP (By similarity).
FT   BINDING     201    201       Substrate (By similarity).
FT   BINDING     205    205       Substrate (By similarity).
FT   BINDING     238    238       NADP (By similarity).
FT   BINDING     357    357       NADP (By similarity).
FT   BINDING     487    487       NADP (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   513 AA;  59126 MW;  655830EB767B6C53 CRC64;
     MAEQVTLSRT QVCGILREEL YQNDAFHQAD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL
     LPKETFIVGY ARSQLTVDDI QKQSEPFFKA TPEERPKLEE FFTRNSYVVG QYDDPASYKH
     LNSYINALHQ GMQANHLFYL ALPPTVYEAV TKNIQETCMS QTGFNRIIVE KPFGRDLQSS
     NQLSNHISSL FREDQIYRID HYLDKEMVQN LMVLRFANRI FGPIWNGDNI VCVILTFKEP
     FGTEGRGGYF DEFGIIRDVM QSHLLQMLCL VAMEKPATTD SDDVRNEKVK VLKCISEVET
     DNVILGQYVG NPNGEGEAAN GYLDDPTVPR GSTTATFAAA VLYVKNERWD GVPFILRCGK
     ALNERKAEVR LQFRDIPGDI FHQKCKRNEL VIRMQPNEAV YTTMMTKKPG MFFNPEESEL
     DLTYGNKYKN VKLPGAYERL ILDVFCGCQM HFVRTDELRE GWRIFTPLLH KIEREKPQPF
     PYVYGSRGPT EADELMRRVG FQYKGTYKGT HKH
//