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UniProtKB/Swiss-Prot entry P94316

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE2_BACFR
Primary accession number P94316
Secondary accession number Q64Q53
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 23, 2004 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 48)
Name and origin of the protein
Protein name NAD-specific glutamate dehydrogenase
Synonyms NAD-GDH
EC 1.4.1.2
NADH-dependent glutamate dehydrogenase
Gene name
Name: gdhB
OrderedLocusNames: BF3635
From
Bacteroides fragilis [TaxID: 817] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidetes (class); Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BF1;
PubMed=9639936 [NCBI, ExPASy, EBI, Israel, Japan]
Abrahams G.L., Abratt V.R.;
"The NADH-dependent glutamate dehydrogenase enzyme of Bacteroides fragilis Bf1 is induced by peptides in the growth medium.";
Microbiology 144:1659-1667(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=YCH46;
DOI=10.1073/pnas.0404172101; PubMed=15466707 [NCBI, ExPASy, EBI, Israel, Japan]
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.";
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U78108; AAC26399.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP006841; BAD50378.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_100912.1; -.
3D structure databases
HSSP P24295; 1AUP. [HSSP ENTRY / PDB]
ModBase P94316.
Enzyme and pathway databases
BioCyc BFRA295405:BF3635-MON; -.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS P94316.
Genome annotation databases
GeneID 3084717; -.
GenomeReviews AP006841_GR; BF3635.
KEGG bfr:BF3635; -.
NMPDR fig|295405.3.peg.3689; -.
Phylogenomic databases
HOGENOM P94316; -.
Genome annotation databases
CMR P94316; BF3635.
Other
ProtoNet P94316.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   445  445     NAD-specific glutamate dehydrogenase. PRO_0000182765
NP_BIND   235   241  7     NAD (Potential). 
ACT_SITE   124   124        By similarity. 
CONFLICT   44    44        S -> A (in Ref. 1; AAC26399). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 48390 Da [This is the MW of the unprocessed precursor] CRC64: E7462E4E6963217B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNIEKIMSSL EAKHPGESEY LQAVKEVLLS IEDIYNQHPE FEKSKIIERL VEPDRIFTFR 

        70         80         90        100        110        120 
VTWVDDKGEV QTNLGYRVQF NNAIGPYKGG IRFHASVNLS ILKFLGFEQT FKNALTTLPM 

       130        140        150        160        170        180 
GGGKGGSDFS PRGKSDAEIM RFCQAFMLEL WRHLGPDMDV PAGDIGVGGR EVGYMFGMYK 

       190        200        210        220        230        240 
KLTREFTGTF TGKGLEFGGS LIRPEATGFG GLYFVNQMLQ TKGIDIKGKT VAISGFGNVA 

       250        260        270        280        290        300 
WGAATKATEL GAKVVTISGP DGYIYDPNGI SGEKIDYMLE LRASGNDIVA PYADEFPGST 

       310        320        330        340        350        360 
FVAGKRPWEV KADIALPCAT QNELNGEDAK NLIDNNVLCV GEISNMGCTP EAIDLFIEHK 

       370        380        390        400        410        420 
TMYAPGKAVN AGGVATSGLE MSQNAMHLSW SAAEVDEKLH SIMHGIHAQC VKYGTEPDGY 

       430        440 
INYVKGANIA GFMKVAHAMM GQGII
P94316 in FASTA format

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