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UniProtKB/Swiss-Prot entry P93596

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP51_WHEAT
Primary accession number P93596
Secondary accession number P93595
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Cytochrome P450 51 [Fragment]
Synonyms EC 1.14.13.70
CYPLI
P450-LIA1
Obtusifoliol 14-alpha demethylase
Gene name
Name: CYP51
From
Triticum aestivum (Wheat) [TaxID: 4565] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Pooideae; Triticeae; Triticum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Darius;
TISSUE=Shoot;
DOI=10.1006/bbrc.1996.5873; PubMed=9016788 [NCBI, ExPASy, EBI, Israel, Japan]
Cabello-Hurtado F., Zimmerlin A., Rahier A., Taton M., Derose R., Nedelkina S., Batard Y., Durst F., Pallett K.E., Werck-Reichhart D.;
"Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat.";
Biochem. Biophys. Res. Commun. 230:381-385(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y09291; CAA70475.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y09292; CAA70476.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T06475; T06475.
3D structure databases
HSSP P77901; 1E9X. [HSSP ENTRY / PDB]
ModBase P93596.
Organism-specific databases
Gramene P93596; -.
Ontologies
GO
GO:0008398; Molecular function: sterol 14-demethylase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002403; Cyt_P450_E_grp-IV.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00465; EP450IV.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS P93596.
Other
ProtoNet P93596.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Lipid synthesis; Membrane; Metal-binding; Methyltransferase; Monooxygenase; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   <1   453  >453     Cytochrome P450 51. PRO_0000052014
METAL   395   395        Iron (heme axial ligand) (By similarity). 
VARIANT   150   150  1     Missing (in clone W516). 
VARIANT   175   175  1     L -> Q (in clone W516). 
VARIANT   443   443  1     N -> S (in clone W516). 
VARIANT   450   450  1     I -> V (in clone W516). 
NON_TER   1     1         
Sequence information
Length: 453 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 51644 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 12A3D00952E3907D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
RPPPTIPGAP VVGGLLRFLR GPIPLIRAEY ARLGPVFTVP ILTRRITFLI GPDVSAHFFK 

        70         80         90        100        110        120 
SNESDMSQQE VYRFNVPTFG PGVVFDVDYQ VRQEQFRFFT EALRANKLRS YVDQMVAEAE 

       130        140        150        160        170        180 
EYFSKWGESG TVDLKYELEH LIILTASRCL LGREVREKLF DDVSALFHDL DNGMLPISVI 

       190        200        210        220        230        240 
FPYLPIPAHR RRDQARTRLA EIFATIIKSR KASGQSEEDM LQCFIDSKYK NGRQTTESEV 

       250        260        270        280        290        300 
TGLLIAALFA GQHTSSITST WTGAYLLKFQ QYFAEAVEEQ KEVMKRHGDK IDHDILAEMD 

       310        320        330        340        350        360 
VLYRCIKEAL RLHPPLIMLL RQSHSDFSVT TREGKEFDIP KGHIVATSPA FANRLPHIFK 

       370        380        390        400        410        420 
NPDSYDPDRF AAGREEDKVA GAFSYISFGG GRHGCLGEPF AYLQIKAIWT HLLRNFEFEL 

       430        440        450 
VSPFPENDWN AMVVGIKGEV MVNYKRRKLI VDN
P93596 in FASTA format

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