NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 62-94, AND MASS SPECTROMETRY.
TISSUE=Bone marrow, and Leukocyte;
PubMed=10531277 [NCBI, ExPASy, EBI, Israel, Japan]
Tang Y.Q., Yuan J., Miller C.J., Selsted M.E.;
"Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.";
Infect. Immun. 67:6139-6144(1999).

Comments

FUNCTION: Defensins 6 and 7 have bacteriostatic activity against Gram-positive bacteria S.aureus and L.monocytogenes and Gram-negative bacterium E.coli and antifungal activity against C.neoformans. Defensin 7 has microbicidial activity against Gram-positive bacteria S.aureus and L.monocytogenes.
SUBCELLULAR LOCATION: Secreted.
MASS SPECTROMETRY: Mass=3898.0; Method=MALDI; Range=62-94; Source=PubMed:10531277;.
MASS SPECTROMETRY: Mass=3740.0; Method=MALDI; Range=63-94; Source=PubMed:10531277;.
SIMILARITY: Belongs to the alpha-defensin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF188272; AAF06316.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

F59076; F59076.
G59076; G59076.

UniGene

Mmu.3478

3D structure databases

ModBase

P82320.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from InterPro).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
GO:0050832;	Biological process: defense response to fungus (inferred from electronic annotation from UniProtKB-KW).
GO:0006805;	Biological process: xenobiotic metabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR016327; Alpha-defensin.
IPR006081; Defensin_alpha.
IPR006080; Defensin_mammal.
IPR002366; Defensin_propep.
Graphical view of domain structure.

Pfam

PF00323; Defensin_1; 1.
PF00879; Defensin_propep; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001875; Alpha-defensin; 1.

SMART

SM00048; DEFSN; 1.
SMART graphical view of domain structure.

PROSITE

PS00269; DEFENSIN; 1.

Genome annotation databases

Ensembl

ENSMMUG00000017957; Macaca mulatta. [Contig view]

Phylogenomic databases

HOVERGEN

P82320; -.

Other

ProtoNet

P82320.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Defensin; Direct protein sequencing; Fungicide; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`PROPEP`	`20 61`	`42`		`PRO_0000006802`
`PEPTIDE`	`62 94`	`33`	`Neutrophil defensin 6.`	`PRO_0000006803`
`PEPTIDE`	`63 94`	`32`	`Neutrophil defensin 7.`	`PRO_0000006804`
`DISULFID`	`65 92`		`By similarity.`
`DISULFID`	`67 82`		`By similarity.`
`DISULFID`	`72 93`		`By similarity.`

Sequence information

Length: 94 AA [This is the length of the unprocessed precursor]

Molecular weight: 10307 Da [This is the MW of the unprocessed precursor]

CRC64: E06932080A06CCD2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRTIAILAAI LLFALLAQAK SLQETADEAA TQEQPGEDDQ DLAVSFEENG LSTLRASGSQ 

        70         80         90 
ARRTCRCRFG RCFRRESYSG SCNINGRISS LCCR

P82320 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools