PROTEIN SEQUENCE.
STRAIN=cv. Romano;
TISSUE=Tuber;
PubMed=9729464 [NCBI, ExPASy, EBI, Israel, Japan]
Millar A.H., Knorpp C., Leaver C.J., Hill S.A.;
"Plant mitochondrial pyruvate dehydrogenase complex: purification and identification of catalytic components in potato.";
Biochem. J. 334:571-576(1998).

Comments

FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate.
SUBUNIT: Tetramer of 2 alpha and 2 beta subunits (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004739;	Molecular function: pyruvate dehydrogenase (acetyl-transferring) activity (inferred from electronic annotation from EC).
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Family and domain databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycolysis; Mitochondrion; Oxidoreductase; Phosphoprotein; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >16`	`>16`	`Pyruvate dehydrogenase E1 component subunit beta, mitochondrial.`	`PRO_0000162217`
`NON_TER`	`16 16`

Sequence information

Length: 16 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 1705 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: FF6ED80EC804F797 [This is a checksum on the sequence]

        10 
ISAVKEMTVR DALNSA

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools