ID   VORC_METTM              Reviewed;          24 AA.
AC   P80909;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   04-NOV-2008, entry version 42.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorC;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
DE   Flags: Fragment;
GN   Name=vorC;
OS   Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133).
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   MEDLINE=97261844; PubMed=9108258;
RA   Tersteegen A., Linder D., Thauer R.K., Hedderich R.;
RT   "Structures and functions of four anabolic 2-oxoacid oxidoreductases
RT   in Methanobacterium thermoautotrophicum.";
RL   Eur. J. Biochem. 244:862-868(1997).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 2 4Fe-4S clusters (By similarity).
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 9.7;
CC       Temperature dependence:
CC         Optimum temperature is 75 degrees Celsius;
CC   -!- SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits.
CC   -!- SIMILARITY: Contains at least 1 4Fe-4S ferredoxin-type domain.
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DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd.
DR   PROSITE; PS00198; 4FE4S_FER_1; PARTIAL.
DR   PROSITE; PS51379; 4FE4S_FER_2; FALSE_NEG.
PE   1: Evidence at protein level;
KW   4Fe-4S; Direct protein sequencing; Electron transport; Iron;
KW   Iron-sulfur; Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    >24       Ketoisovalerate oxidoreductase subunit
FT                                vorC.
FT                                /FTId=PRO_0000099960.
FT   DOMAIN        4    >24       4Fe-4S ferredoxin-type.
FT   METAL        13     13       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        16     16       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        19     19       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   UNSURE       13     13
FT   UNSURE       16     16
FT   UNSURE       19     19
FT   NON_TER      24     24
SQ   SEQUENCE   24 AA;  2748 MW;  6E3CA79596800DC9 CRC64;
     MKKAYPVINR VECXACERCI IQAP
//