PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=8612631 [NCBI, ExPASy, EBI, Israel, Japan]
Shafqat J., Hjelmqvist L., Joernvall H.;
"Liver class-I alcohol dehydrogenase isozyme relationships and constant patterns in a variable basic structure. Distinctions from characterization of an ethanol dehydrogenase in cobra, Naja naja.";
Eur. J. Biochem. 236:571-578(1996).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	S62640; S62640.
3D structure databases
HSSP	P00326; 1HT0. [HSSP ENTRY / PDB]
SMR	P80512; 1-375.
ModBase	P80512.
Family and domain databases
InterPro	IPR013154; AlcDHase_GroES-like. IPR002085; AlcDHase_SF_Zn. IPR013149; AlcDHase_Zn-bd. IPR002328; AlcDHase_Zn_CS. Graphical view of domain structure.
PANTHER	PTHR11695; ADH_Sf_Zn; 1.
Pfam	PF08240; ADH_N; 1. PF00107; ADH_zinc_N; 1. Pfam graphical view of domain structure.
PROSITE	PS00059; ADH_ZINC; 1.
BLOCKS	P80512.
Phylogenomic databases
HOVERGEN	P80512; -.
Other
ProtoNet	P80512.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 375`	`375`	`Alcohol dehydrogenase 1.`	`PRO_0000160676`
`METAL`	`46 46`		`Zinc 1; catalytic (By similarity).`
`METAL`	`67 67`		`Zinc 1; catalytic (By similarity).`
`METAL`	`97 97`		`Zinc 2 (By similarity).`
`METAL`	`100 100`		`Zinc 2 (By similarity).`
`METAL`	`103 103`		`Zinc 2 (By similarity).`
`METAL`	`111 111`		`Zinc 2 (By similarity).`
`METAL`	`174 174`		`Zinc 1; catalytic (By similarity).`
`MOD_RES`	`1 1`		`N-acetylserine.`

Sequence information

Length: 375 AA [This is the length of the unprocessed precursor]

Molecular weight: 39955 Da [This is the MW of the unprocessed precursor]

CRC64: 6EDC9E505631EC13 [This is a checksum on the sequence]

        10         20         30         40         50         60 
STAGKVIKCK AAIAWELNKP LSIEQIEVAP PKAHEVRIKI LATGVCRSDE HVISGAFRMP 

        70         80         90        100        110        120 
LPMVLGHEAA GVVESVGEGV TCVKPGDKVI PLFAPQCGKC RACQSPKGNL CTSNDLNSGS 

       130        140        150        160        170        180 
GLMPDGTSRF TCKGKSIHHF ISTSTFTEYT VVHENSVVKI DPSAPLEKVC LIGCGFSTGY 

       190        200        210        220        230        240 
GAAMQTAKVE PGSICAVFGL GGVGLSVVMG CKAAGASRII GVDINKDKFA KAKEMGATEC 

       250        260        270        280        290        300 
INPLDFKKPI NEVLFDLTGG EGVDYSFEVI GRTETMISAF TSCHQNLGTS VVVGVPPNAS 

       310        320        330        340        350        360 
MITYNPLMLF TGRTWKGCVF GGWKSKDSVP KLVSDFMQKK FVLDPLITHT LPFEKINEGF 

       370 
DLLRSGKSIR TVLIF

P80512 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools