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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Urogenital ridge;
PubMed=8395914 [NCBI, ExPASy, EBI, Israel, Japan]
He W.-W.,
Gustafson M.L.,
Hirobe S.,
Donahoe P.K.;
"Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family.";
Dev. Dyn. 196:133-142(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
TISSUE=Lung;
PubMed=8928814 [NCBI, ExPASy, EBI, Israel, Japan]
Panchenko M.P.,
Williams M.C.,
Brody J.S.,
Yu Q.;
"Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels.";
Am. J. Physiol. 270:L547-L558(1996).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
- COFACTOR: Magnesium or manganese (By similarity).
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.
- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
- SIMILARITY: Contains 1 GS domain.
- SIMILARITY: Contains 1 protein kinase domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 504 AA [This is the length of the unprocessed precursor] |
Molecular weight: 56703 Da [This is the MW of the unprocessed precursor] |
CRC64: B40EA30775223C8F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ
70 80 90 100 110 120
GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL
130 140 150 160 170 180
PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV
190 200 210 220 230 240
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW
250 260 270 280 290 300
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA
310 320 330 340 350 360
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS
370 380 390 400 410 420
DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE
430 440 450 460 470 480
DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR
490 500
LTALRIKKTL QKLSQNPEKP KVIH
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P80203 in FASTA format |
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