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UniProtKB/Swiss-Prot entry P79153

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP11A_CAPHI
Primary accession number P79153
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on May 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 47)
Name and origin of the protein
Protein name Cytochrome P450 11A1, mitochondrial [Precursor]
Synonyms EC 1.14.15.6
CYPXIA1
Cholesterol side-chain cleavage enzyme
P450(scc)
Cholesterol desmolase
Gene name
Name: CYP11A1
From
Capra hircus (Goat) [TaxID: 9925] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal cortex;
DOI=10.1016/0960-0760(95)00263-4; PubMed=8645627 [NCBI, ExPASy, EBI, Israel, Japan]
Okuyama E., Okazaki T., Furukawa A., Wu R.-F., Ichikawa Y.;
"Molecular cloning and nucleotide sequences of cDNA clones of sheep and goat adrenocortical cytochromes P450scc (CYP11A1).";
J. Steroid Biochem. Mol. Biol. 57:179-185(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D50058; BAA08776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase P79153.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS P79153.
Phylogenomic databases
HOVERGEN P79153; -.
Other
ProtoNet P79153.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol metabolism; Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroid metabolism; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    39  39     Mitochondrion (By similarity). 
CHAIN   40   520  481     Cytochrome P450 11A1, mitochondrial. PRO_0000003583
METAL   461   461        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 520 AA [This is the length of the unprocessed precursor] Molecular weight: 60418 Da [This is the MW of the unprocessed precursor] CRC64: 4FB09A3C89310317 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLARGLPLRS ALVKACPPLL NTGREGWGHH RVGTGEGAGI STRTPRPYSE IPSPGDNGWI 

        70         80         90        100        110        120 
NLYHFWRKKS SQRIHFRHIE NFQKYGPIYR EKLGNLESVY IIHPEDVAHL FKFEGSYPQR 

       130        140        150        160        170        180 
YDIPPWLAYH QYYQKPIGVL FKKSGAWKKD RVVLNTEVMA PEAIKNFIPL LNPVSQDFVS 

       190        200        210        220        230        240 
LLRKRIQQQG SGKFAGDIKE DLFHFAFESI TNVMFGERLG MLEDTVNTEA QKFIDAVYKM 

       250        260        270        280        290        300 
FHTSVPLLNL PPELYRLFRT KTWRDHVAAW DTIFNKAEKY TEIFYQDLRQ KTEFRNYPGI 

       310        320        330        340        350        360 
LYHLLKSEKM LLEDVKANIT EMLAGGVDTT SMTLQWHLYE MARSLNVQEM LREEVLNARR 

       370        380        390        400        410        420 
QAEGDISKML QMVPLLKASI KETLRLHPIS VTLQRYPESD LVLQDYLIPA KTLVQVAIYA 

       430        440        450        460        470        480 
MGRDPAFFSN PDKFDPTRWL GKDKDLIHFR NLGFGWGVRQ CVGRRIAELE MTLFLIHILE 

       490        500        510        520 
NFKIEMQQIG DVNTIFNLIL TPDKPIFLVF RPFNQDPPQA
P79153 in FASTA format

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