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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/385640a0; PubMed=9024663 [NCBI, ExPASy, EBI, Israel, Japan]
Bazan J.F.,
Bacon K.B.,
Hardiman G.,
Wang W.,
Soo K.,
Rossi D.,
Greaves D.R.,
Zlotnik A.,
Schall T.J.;
"A new class of membrane-bound chemokine with a CX3C motif.";
Nature 385:640-644(1997).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1006/geno.1999.5927; PubMed=10493829 [NCBI, ExPASy, EBI, Israel, Japan]
Loftus B.J.,
Kim U.-J.,
Sneddon V.P.,
Kalush F.,
Brandon R.,
Fuhrmann J.,
Mason T.,
Crosby M.L.,
Barnstead M.,
Cronin L.,
Mays A.D.,
Cao Y.,
Xu R.X.,
Kang H.-L.,
Mitchell S.,
Eichler E.E.,
Harris P.C.,
Venter J.C.,
Adams M.D.;
"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.";
Genomics 60:295-308(1999).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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STRUCTURE BY NMR OF 25-100.
DOI=10.1021/bi9820614; PubMed=9931005 [NCBI, ExPASy, EBI, Israel, Japan]
Mizoue L.S.,
Bazan J.F.,
Johnson E.C.,
Handel T.M.;
"Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.";
Biochemistry 38:1402-1414(1999).
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- FUNCTION: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
- SUBCELLULAR LOCATION: Processed fractalkine: Secreted.
- TISSUE SPECIFICITY: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
- INDUCTION: By TNF and IL-1 in pulmonary endothelial cells and umbilical vein endothelial cells.
- PTM: A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form (By similarity).
- SIMILARITY: Belongs to the intercrine delta family.
- WEB RESOURCE: Name=Wikipedia; Note=CX3CL1 entry; URL="http://en.wikipedia.org/wiki/CX3CL1";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 397 AA [This is the length of the unprocessed precursor] |
Molecular weight: 42203 Da [This is the MW of the unprocessed precursor] |
CRC64: BAC71F5080DF9CA6 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAPISLSWLL RLATFCHLTV LLAGQHHGVT KCNITCSKMT SKIPVALLIH YQQNQASCGK
70 80 90 100 110 120
RAIILETRQH RLFCADPKEQ WVKDAMQHLD RQAAALTRNG GTFEKQIGEV KPRTTPAAGG
130 140 150 160 170 180
MDESVVLEPE ATGESSSLEP TPSSQEAQRA LGTSPELPTG VTGSSGTRLP PTPKAQDGGP
190 200 210 220 230 240
VGTELFRVPP VSTAATWQSS APHQPGPSLW AEAKTSEAPS TQDPSTQAST ASSPAPEENA
250 260 270 280 290 300
PSEGQRVWGQ GQSPRPENSL EREEMGPVPA HTDAFQDWGP GSMAHVSVVP VSSEGTPSRE
310 320 330 340 350 360
PVASGSWTPK AEEPIHATMD PQRLGVLITP VPDAQAATRR QAVGLLAFLG LLFCLGVAMF
370 380 390
TYQSLQGCPR KMAGEMAEGL RYIPRSCGSN SYVLVPV
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P78423 in FASTA format |
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ExPASy Home page
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