[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/0014-5793(94)00587-7; PubMed=8026587 [NCBI, ExPASy, EBI, Israel, Japan]
Kikuta Y.,
Kusunose E.,
Kondo T.,
Yamamoto S.,
Kinoshita H.,
Kusunose M.;
"Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.";
FEBS Lett. 348:70-74(1994).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Chen L.,
Hardwick J.P.;
"The human liver CYP4F2 cDNA sequence and expression in baculovirus-infected insect cells.";
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1089/104454999315006; PubMed=10492403 [NCBI, ExPASy, EBI, Israel, Japan]
Kikuta Y.,
Miyauchi Y.,
Kusunose E.,
Kusunose M.;
"Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.";
DNA Cell Biol. 18:723-730(1999).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TYR-7; GLY-12; VAL-185; MET-433 AND MET-519.
SeattleSNPs program for genomic applications;
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J.,
Gordon L.A.,
Olsen A.S.,
Terry A.,
Schmutz J.,
Lamerdin J.E.,
Hellsten U.,
Goodstein D.,
Couronne O.,
Tran-Gyamfi M.,
Aerts A.,
Altherr M.,
Ashworth L.,
Bajorek E.,
Black S.,
Branscomb E.,
Caenepeel S.,
Carrano A.V.,
Caoile C., ![]()
Chan Y.M.,
Christensen M.,
Cleland C.A.,
Copeland A.,
Dalin E.,
Dehal P.,
Denys M.,
Detter J.C.,
Escobar J.,
Flowers D.,
Fotopulos D.,
Garcia C.,
Georgescu A.M.,
Glavina T.,
Gomez M.,
Gonzales E.,
Groza M.,
Hammon N.,
Hawkins T.,
Haydu L.,
Ho I.,
Huang W.,
Israni S.,
Jett J.,
Kadner K.,
Kimball H.,
Kobayashi A.,
Larionov V.,
Leem S.-H.,
Lopez F.,
Lou Y.,
Lowry S.,
Malfatti S.,
Martinez D.,
McCready P.M.,
Medina C.,
Morgan J.,
Nelson K.,
Nolan M.,
Ovcharenko I.,
Pitluck S.,
Pollard M.,
Popkie A.P.,
Predki P.,
Quan G.,
Ramirez L.,
Rash S.,
Retterer J.,
Rodriguez A.,
Rogers S.,
Salamov A.,
Salazar A.,
She X.,
Smith D.,
Slezak T.,
Solovyev V.,
Thayer N.,
Tice H.,
Tsai M.,
Ustaszewska A.,
Vo N.,
Wagner M.,
Wheeler J.,
Wu K.,
Xie G.,
Yang J.,
Dubchak I.,
Furey T.S.,
DeJong P.,
Dickson M.,
Gordon D.,
Eichler E.E.,
Pennacchio L.A.,
Richardson P.,
Stubbs L.,
Rokhsar D.S.,
Myers R.M.,
Rubin E.M.,
Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-12 AND MET-433.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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NUCLEOTIDE SEQUENCE OF 1-175.
TISSUE=Liver;
DOI=10.1006/abbi.2000.1836; PubMed=10860554 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang X.,
Chen L.,
Hardwick J.P.;
"Promoter activity and regulation of the CYP4F2 leukotriene B4 omega hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.";
Arch. Biochem. Biophys. 378:364-376(2000).
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- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- CATALYTIC ACTIVITY: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.
- COFACTOR: Heme group (By similarity).
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
- TISSUE SPECIFICITY: Liver.
- SIMILARITY: Belongs to the cytochrome P450 family.
- WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cyp4f2/";.
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