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UniProtKB/Swiss-Prot entry P77872


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CATA_HELPY
Primary accession number P77872
Secondary accession number P94823
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    October 14, 2008 (Entry version 60)
Name and origin of the protein
Protein name Catalase
Synonym EC 1.11.1.6
Gene name
Name: katA
OrderedLocusNames: HP_0875
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=RU1;
DOI=10.1046/j.1523-5378.1998.08030.x; PubMed=9546115 [NCBI, ExPASy, EBI, Israel, Japan]
Manos J., Kolesnikow T., Hazell S.L.;
"An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori.";
Helicobacter 3:28-38(1998).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=P1;
PubMed=8955320 [NCBI, ExPASy, EBI, Israel, Japan]
Odenbreit S., Wieland B., Haas R.;
"Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain.";
J. Bacteriol. 178:6960-6967(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U67458; AAC16068.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z70679; CAA94567.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000511; AAD07923.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C64629; C64629.
RefSeq NP_207669.1; -.
3D structure databases
PDB
1QWL; X-ray; 1.60 A; A/B=1-505.[ExPASy / RCSB / EBI]
1QWM; X-ray; 1.60 A; A/B=1-505.[ExPASy / RCSB / EBI]
2A9E; X-ray; 1.76 A; A/B=1-505.[ExPASy / RCSB / EBI]
2IQF; X-ray; 1.86 A; A/B=1-505.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1QWL; -.
1QWM; -.
2A9E; -.
2IQF; -.
ModBase P77872.
Protein-protein interaction databases
DIP DIP:3559N; -.
Family and domain databases
InterPro IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.
Gene3D G3DSA:2.40.180.10; Catalase_N; 1.
PANTHER PTHR11465; Catalase; 1.
Pfam PF00199; Catalase; 1.
Pfam graphical view of domain structure.
PRINTS PR00067; CATALASE.
ProDom PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
PS51402; CATALASE_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P77872.
Genome annotation databases
GeneID 899404; -.
GenomeReviews AE000511_GR; HP_0875.
KEGG hpy:HP0875; -.
NMPDR fig|85962.1.peg.866; -.
TIGR HP_0875; -.
Phylogenomic databases
HOGENOM P77872; -.
Other
ProtoNet P77872.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Cytoplasm; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   505  505     Catalase. PRO_0000084987
ACT_SITE   56    56        By similarity. 
ACT_SITE   129   129        By similarity. 
METAL   339   339        Iron (heme axial ligand) (By similarity). 
CONFLICT   82    82        S -> F (in Ref. 1; AAC16068). 
CONFLICT   234   234        V -> I (in Ref. 2; CAA94567). 
CONFLICT   237   237        Y -> H (in Ref. 2; CAA94567). 
CONFLICT   248   248        N -> D (in Ref. 2; CAA94567). 
CONFLICT   255   255        F -> Y (in Ref. 2; CAA94567). 
CONFLICT   286   286        L -> T (in Ref. 2; CAA94567). 
CONFLICT   313   313        A -> V (in Ref. 1; AAC16068). 
CONFLICT   316   316        S -> T (in Ref. 2; AAC16068/CAA94567). 
STRAND   24    26  3      
HELIX   36    45  10      
STRAND   58    68  11      
TURN   73    75  3      
HELIX   79    81  3      
STRAND   87    95  9      
STRAND   105   109  5      
STRAND   112   119  8      
STRAND   122   132  11      
HELIX   139   141  3      
HELIX   142   149  8      
TURN   153   155  3      
HELIX   160   169  10      
HELIX   171   173  3      
HELIX   174   181  8      
HELIX   183   185  3      
STRAND   186   189  4      
HELIX   190   192  3      
STRAND   201   204  4      
STRAND   210   219  10      
HELIX   228   235  8      
HELIX   241   251  11      
STRAND   257   266  10      
HELIX   267   269  3      
TURN   270   272  3      
TURN   286   288  3      
STRAND   292   301  10      
HELIX   306   309  4      
TURN   310   312  3      
HELIX   330   347  18      
HELIX   351   353  3      
HELIX   355   357  3      
TURN   376   379  4      
STRAND   387   389  3      
HELIX   395   397  3      
HELIX   404   406  3      
HELIX   418   421  4      
HELIX   427   435  9      
HELIX   438   452  15      
HELIX   458   471  14      
HELIX   473   489  17      
Sequence information
Length: 505 AA [This is the length of the unprocessed precursor] Molecular weight: 58629 Da [This is the MW of the unprocessed precursor] CRC64: 9F029B55B73C26EA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI PERVVHAKGS 

        70         80         90        100        110        120 
GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE RGSADAVRDP RGFAMKYYTE 

       130        140        150        160        170        180 
EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK RDPQTNLPNH DMVWDFWSNV PESLYQVTWV 

       190        200        210        220        230        240 
MSDRGIPKSF RHMDGFGSHT FSLINAKGER FWVKFHFHTM QGVKHLTNEE AAEVRKYDPD 

       250        260        270        280        290        300 
SNQRDLFNAI ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLQDYP LMEVGIVELN 

       310        320        330        340        350        360 
KNPENYFAEV EQAAFSPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN YPQIPVNKPR 

       370        380        390        400        410        420 
CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP KFNLAHIEKE FEVWNWDYRA 

       430        440        450        460        470        480 
DDSDYYTQPG DYYRSLPADE KERLHDTIGE SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK 

       490        500 
KALEKHQKMM KDMHGKDMHH TKKKK 

P77872 in FASTA format

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