ID   P5CR_SYNY3              Reviewed;         267 AA.
AC   P74572;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   16-DEC-2008, entry version 47.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=slr0661;
OS   Synechocystis sp. (strain PCC 6803).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
OX   NCBI_TaxID=1148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA   Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA   Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA   Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT   entire genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; BA000022; BAA18679.1; -; Genomic_DNA.
DR   PIR; S76767; S76767.
DR   RefSeq; NP_442867.1; -.
DR   IntAct; P74572; 1.
DR   GeneID; 952360; -.
DR   GenomeReviews; BA000022_GR; slr0661.
DR   KEGG; syn:slr0661; -.
DR   NMPDR; fig|1148.1.peg.2968; -.
DR   HOGENOM; P74572; -.
DR   BioCyc; SSP1148:SLR0661-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    267       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187308.
SQ   SEQUENCE   267 AA;  27883 MW;  FD9C428047F391B0 CRC64;
     MSIQLGIIGG GVMAEAILAR LIAEKTYAPE EIIVGEPHGA RRDYLQKTYQ VRVSPDNQEA
     ANVSEVLLLA VKPQVLDRVL ASLAGGANRP LVISILAGVS LQRIQKGFPD HAIIRAMPNT
     PATVGAGMTA IAANKMVEPD QLAKAKAIFS AVGNVVEVPE NLMDAVTGVS GSGPAYVALM
     IEALADGGVL AGLPRAIAQK LALQTVLGTA ELIKETEEHP AQIKDKVTSP GGTTIAGVAV
     LEKMGFRSAI IEAVRAAYRR SQELGKK
//