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UniProtKB/Swiss-Prot entry P69084

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_GILSE
Primary accession number P69084
Secondary accession number O93620
Integrated into Swiss-Prot on February 15, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Gillichthys seta (Shortjaw mudsucker) [TaxID: 79683] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Gobioidei; Gobiidae; Gobionellinae; Gillichthys.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
PubMed=9319749 [NCBI, ExPASy, EBI, Israel, Japan]
Fields P., Somero G.;
"Amino acid sequence differences cannot fully explain interspecific variation in thermal sensitivities of gobiid fish A4-lactate dehydrogenases (A4-LDHs).";
J. Exp. Biol. 200:1839-1850(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF079533; AAC31198.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P07195; 1I0Z. [HSSP ENTRY / PDB]
SMR P69084; 2-332.
ModBase P69084.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P69084.
Phylogenomic databases
HOVERGEN P69084; -.
Other
ProtoNet P69084.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168440
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36235 Da [This is the MW of the unprocessed precursor] CRC64: 74507E0676453905 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTKEKLISH VSKEEAVGSR NKVTVVGVGM VGMASAISIL LKDLCDELAL VDVMEDKLKG 

        70         80         90        100        110        120 
EVMDLQHGSL FLKTHKIVAD KDYSVTANSR VVVVTAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNIVKYSPN CILMVVSNPV DILTYVAWKL SGFPRHRVIG SGTNLDSARF RHIMGEKLHL 

       190        200        210        220        230        240 
HPSSCHGWIV GEHGDSSVPV WSGVNVAGVS LQTLNPKMGA EGDSENWKAV HKMVVDGAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGMSVADLV ESIVKNLHKV HPVSTLVKGM HGVKDEVFLS VPCVLGNSGL 

       310        320        330 
TDVIHMTLKA DEEKQLVKSA ETLWGVQKEL TL
P69084 in FASTA format

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