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UniProtKB/Swiss-Prot entry P69082

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_PAGBE
Primary accession number P69082
Secondary accession number O93619
Integrated into Swiss-Prot on February 15, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Pagothenia bernacchii (Emerald rockcod) (Trematomus bernacchii) [TaxID: 40690] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Notothenioidei; Nototheniidae; Trematomus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
Marshall C.J., Sharpe M.L., Love C.A.;
"Cold adaptation in lactate dehydrogenases from Antarctic fish.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF170847; AAD48487.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00336; 5LDH. [HSSP ENTRY / PDB]
SMR P69082; 2-331.
ModBase P69082.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P69082.
Phylogenomic databases
HOVERGEN P69082; -.
Other
ProtoNet P69082.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   331  330     L-lactate dehydrogenase A chain. PRO_0000168446
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   192   192        Proton acceptor (By similarity). 
BINDING   98    98        NAD (By similarity). 
BINDING   105   105        Substrate (By similarity). 
BINDING   137   137        NAD or substrate (By similarity). 
BINDING   168   168        Substrate (By similarity). 
BINDING   247   247        Substrate (By similarity). 
Sequence information
Length: 331 AA [This is the length of the unprocessed precursor] Molecular weight: 36183 Da [This is the MW of the unprocessed precursor] CRC64: 6C626409CA0FDAE9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTKEKLISH VMKEEPVGSR NKVTVVGVGM VGMASAISIL LKDLCDELAM VDVMEDKLKG 

        70         80         90        100        110        120 
EVMDLQHGSL FLKTKIVGDK DYSVTANSKV VVVTAGARQQ EGESRLNLVQ RNVNIFKFII 

       130        140        150        160        170        180 
PNIVKYSPNC ILMVVSNPVD ILTYVAWKLS GFPRHRVIGS GTNLDSARFR HLIGEKLHLH 

       190        200        210        220        230        240 
PSSCHAWIVG EHGDSSVPVW SGVNVAGVSL QGLNPQMGTE GDGENWKAIH KEVVDGAYEV 

       250        260        270        280        290        300 
IKLKGYTSWA IGMSVADLVE SIIKNMHKVH PVSTLVQGMH GVKDEVFLSV PCVLGNSGLT 

       310        320        330 
DVIHMTLKAE EEKQLQKSAE TLWGVQKELT L
P69082 in FASTA format

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