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UniProtKB/Swiss-Prot entry P65563


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUOA_MYCTU
Primary accession number P65563
Secondary accession number P95181
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 25)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
OrderedLocusNames: Rv3145, MT3233
ORFNames: MTCY03A2.13c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842582; CAB06271.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK47572.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B70647; B70647.
RefSeq NP_217661.1; -.
NP_337758.1; -.
3D structure databases
ModBase P65563.
Organism-specific databases
TubercuList Rv3145; -.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
BLOCKS P65563.
Genome annotation databases
GeneID 887397; -.
923389; -.
GenomeReviews AE000516_GR; MT3233.
AL123456_GR; Rv3145.
KEGG mtc:MT3233; -.
mtu:Rv3145; -.
TIGR MT3233; -.
Phylogenomic databases
HOGENOM P65563; -.
Other
ProtoNet P65563.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   128  128     NADH-quinone oxidoreductase subunit A. PRO_0000117870
TRANSMEM   5    25  21     Potential. 
TRANSMEM   72    92  21     Potential. 
TRANSMEM   100   120  21     Potential. 
Sequence information
Length: 128 AA [This is the length of the unprocessed precursor] Molecular weight: 13975 Da [This is the MW of the unprocessed precursor] CRC64: DDF4FD3F77A8149A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNVYIPILVL AALAAAFAVV SVVIASLVGP SRFNRSKQAA YECGIEPAST GARTSIGPGA 

        70         80         90        100        110        120 
ASGQRFPIKY YLTAMLFIVF DIEIVFLYPW AVSYDSLGTF ALVEMAIFML TVFVAYAYVW 


RRGGLTWD 

P65563 in FASTA format

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View entry in raw text format (no links)
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