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UniProtKB/Swiss-Prot entry P64174


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FRDA_MYCTU
Primary accession number P64174
Secondary accession number Q10760
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Fumarate reductase flavoprotein subunit
Synonym EC 1.3.99.1
Gene name
Name: frdA
OrderedLocusNames: Rv1552, MT1603
ORFNames: MTCY48.13c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842577; CAA98311.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK45870.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E70762; E70762.
RefSeq NP_216068.1; -.
NP_336056.1; -.
3D structure databases
HSSP P00363; 1KF6. [HSSP ENTRY / PDB]
ModBase P64174.
Organism-specific databases
TubercuList Rv1552; -.
Ontologies
GO
GO:0000104; Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR005884; Fum_red_fp.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.
Pfam PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00411; PNDRDTASEI.
TIGRFAMs TIGR01176; fum_red_Fp; 1.
TIGR01812; sdhA_frdA_Gneg; 1.
PROSITE PS00504; FRD_SDH_FAD_BINDING; 1.
BLOCKS P64174.
Genome annotation databases
GeneID 886376; -.
924332; -.
GenomeReviews AE000516_GR; MT1603.
AL123456_GR; Rv1552.
KEGG mtc:MT1603; -.
mtu:Rv1552; -.
TIGR MT1603; -.
Phylogenomic databases
HOGENOM P64174; -.
Other
ProtoNet P64174.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Electron transport; FAD; Flavoprotein; Oxidoreductase; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   583  583     Fumarate reductase flavoprotein subunit. PRO_0000158664
NP_BIND   8    22  15     FAD (By similarity). 
ACT_SITE   232   232        By similarity. 
ACT_SITE   248   248        By similarity. 
MOD_RES   44    44        Tele-8alpha-FAD histidine (By similarity). 
Sequence information
Length: 583 AA [This is the length of the unprocessed precursor] Molecular weight: 63763 Da [This is the MW of the unprocessed precursor] CRC64: 5B1726413767FA63 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTAQHNIVVI GGGGAGLRAA IAIAETNPHL DVAIVSKVYP MRSHTVSAEG GAAAVTGDDD 

        70         80         90        100        110        120 
SLDEHAHDTV SGGDWLCDQD AVEAFVAEAP KELVQLEHWG CPWSRKPDGR VAVRPFGGMK 

       130        140        150        160        170        180 
KLRTWFAADK TGFHLLHTLF QRLLTYSDVM RYDEWFATTL LVDDGRVCGL VAIELATGRI 

       190        200        210        220        230        240 
ETILADAVIL CTGGCGRVFP FTTNANIKTG DGMALAFRAG APLKDMEFVQ YHPTGLPFTG 

       250        260        270        280        290        300 
ILITEAARAE GGWLLNKDGY RYLQDYDLGK PTPEPRLRSM ELGPRDRLSQ AFVHEHNKGR 

       310        320        330        340        350        360 
TVDTPYGPVV YLDLRHLGAD LIDAKLPFVR ELCRDYQHID PVVELVPVRP VVHYMMGGVH 

       370        380        390        400        410        420 
TDINGATTLP GLYAAGETAC VSINGANRLG SNSLPELLVF GARAGRAAAD YAARHQKSDR 

       430        440        450        460        470        480 
GPSSAVRAQA RTEALRLERE LSRHGQGGER IADIRADMQA TLESAAGIYR DGPTLTKAVE 

       490        500        510        520        530        540 
EIRVLQERFA TAGIDDHSRT FNTELTALLE LSGMLDVALA IVESGLRREE SRGAHQRTDF 

       550        560        570        580 
PNRDDEHFLA HTLVHRESDG TLRVGYLPVT ITRWPPGERV YGR 

P64174 in FASTA format

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