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UniProtKB/Swiss-Prot entry P62053

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LACJO
Primary accession number P62053
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on June 21, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: LJ_1403
From
Lactobacillus johnsonii [TaxID: 33959] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 533;
DOI=10.1073/pnas.0307327101; PubMed=14983040 [NCBI, ExPASy, EBI, Israel, Japan]
Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
"The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.";
Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017198; AAS09169.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_965203.1; -.
3D structure databases
ModBase P62053.
Enzyme and pathway databases
BioCyc LJOH257314:LJ_1403-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS P62053.
Genome annotation databases
GeneID 2742261; -.
GenomeReviews AE017198_GR; LJ_1403.
KEGG ljo:LJ1403; -.
NMPDR fig|257314.1.peg.1189; -.
Phylogenomic databases
HOGENOM P62053; -.
Genome annotation databases
CMR P62053; LJ_1403.
Other
ProtoNet P62053.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   308  308     L-lactate dehydrogenase 2. PRO_0000168350
NP_BIND   12    40  29     NAD (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
BINDING   88    88        Substrate (By similarity). 
BINDING   120   120        NAD or substrate (By similarity). 
BINDING   151   151        Substrate (By similarity). 
BINDING   225   225        Substrate (By similarity). 
Sequence information
Length: 308 AA [This is the length of the unprocessed precursor] Molecular weight: 33283 Da [This is the MW of the unprocessed precursor] CRC64: A610A15C82E85C0E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSRRKVFLVG DGRVGSTFAN DLLQNVRIDE LVICDVVKKI TEGDALDLED LAPFVGQCTV 

        70         80         90        100        110        120 
KSGDYSDAKD ADIAVITAGA ARKPGMTRLD LVKTNVKILE SIIKPIVESG FNGIFVVSAN 

       130        140        150        160        170        180 
PVDILTTLTQ KLSGFPKNKV IGTGTSLDTA RLRVALSHKT GVNVDHIDAY VLGEHGDTSF 

       190        200        210        220        230        240 
ENFDEAIIDH KPLRSYKELD EETLVELETD VRKKGGKIIA NKGATFYGVA MCLTQICKAI 

       250        260        270        280        290        300 
LENKALVMPL SAPMTGEYGI HDLYIGSPAV VTANGISDVI ELHLSEDENK KMAYSAAKMK 


EVVDGIDL
P62053 in FASTA format

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