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UniProtKB/Swiss-Prot entry P60200

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRA_METJA
Primary accession number P60200
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on February 26, 2008 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase iron-sulfur subunit A
Synonym EC 1.8.98.1
Gene name
Name: hdrA
OrderedLocusNames: MJ1190
From
Methanocaldococcus jannaschii (Methanococcus jannaschii) [TaxID: 2190] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
PubMed=8688087 [NCBI, ExPASy, EBI, Israel, Japan]
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.";
Science 273:1058-1073(1996).
[2]
 PROBABLE SELENOCYSTEINE AT SEC-196.
DOI=10.1006/jmbi.1996.0812; PubMed=9102456 [NCBI, ExPASy, EBI, Israel, Japan]
Wilting R., Schorling S., Persson B.C., Boeck A.;
"Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion.";
J. Mol. Biol. 266:637-641(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L77117; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
3D structure databases
ModBase P60200.
Ontologies
GO
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR006076; FAD-dep_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01266; DAO; 1.
PF00037; Fer4; 4.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 4.
PS51379; 4FE4S_FER_2; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS P60200.
Genome annotation databases
TIGR MJ1190; -.
Phylogenomic databases
HOGENOM P60200; -.
Other
ProtoNet P60200.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat; Selenium; Selenocysteine.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   657  657     CoB--CoM heterodisulfide reductase iron-sulfur subunit A. PRO_0000150057
DOMAIN   235   266  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   283   312  30     4Fe-4S ferredoxin-type 2. 
DOMAIN   574   603  30     4Fe-4S ferredoxin-type 3. 
DOMAIN   607   636  30     4Fe-4S ferredoxin-type 4. 
NP_BIND   149   172  24     FAD (Potential). 
METAL   245   245        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   248   248        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   251   251        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   255   255        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   292   292        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   295   295        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   298   298        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   302   302        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   583   583        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   586   586        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   589   589        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   593   593        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   616   616        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   619   619        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   622   622        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   626   626        Iron-sulfur 3 (4Fe-4S) (Potential). 
NON_STD   196   196        Selenocysteine (Probable). 
Sequence information
Length: 657 AA [This is the length of the unprocessed precursor] Molecular weight: 71922 Da [This is the MW of the unprocessed precursor] CRC64: D3607042434DBC32 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSPRVGVFVC YCGANINGVV DCEAVRDFAE KLDGVVVAKT YPFMCADPGQ NLIKEAIKEY 

        70         80         90        100        110        120 
NLDRVVVAAC TPKIHEPTFR NCIKEAGLSP YYLEFVNIRE HCSFVHMNDR EKATKKAMEL 

       130        140        150        160        170        180 
VAGAVERAKR LEDVPQKIVE VDKSCLIIGG GIAGIQAALD LGDQGYKVYL VEKEPSIGGR 

       190        200        210        220        230        240 
MAQLAKTFPT DDCALUILAP KMVSVANHPN VELITYAEVK NVEGFIGNFE VTIEKKPRYV 

       250        260        270        280        290        300 
DENICTGCGA CAAVCPIEVP NEFDLGLGTR KAIYVPFAQA VPLVYTIDMD HCIRCGLCEK 

       310        320        330        340        350        360 
ACGPGAIRYD QKPEEIKLKV GTIICAVGYD EFDATLKEEY GYGVYDNVIT TLELERMINP 

       370        380        390        400        410        420 
AGPTGGHEIR PSDGKHPHRV VFIQCVGSRD AKVGKHYCSR ICCMFALKNA QLIKQHDPST 

       430        440        450        460        470        480 
EVYICYMDIR SFGKGYEEYY RRAQEQFGVK FIRGRPACIM EDPETKNLIV RVEDTLLGEI 

       490        500        510        520        530        540 
VEIEADLVVL SAGLSPRPDN PKLAKMLGLE LSPDGFFKEL HPKLAPVNTK VDGIAIAGVA 

       550        560        570        580        590        600 
QGPKDIPDTV AQAKGAASAV SIPMAQGQFR IEMIRAVVDE DVCGGCQVCA KMCPYNAITY 

       610        620        630        640        650 
VEKDGHLVAQ VNDVACKGCG SCAGACPSGA MQLRYYRDEQ IISFIDGVLE AHQKLES
P60200 in FASTA format

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