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UniProtKB/Swiss-Prot entry P59443


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_BUCBP
Primary accession number P59443
Secondary accession numbers None
Integrated into Swiss-Prot on March 28, 2003
Sequence was last modified on March 28, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 41)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: bbp_188
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO26920.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777815.1; -.
3D structure databases
HSSP P12268; 1B3O. [HSSP ENTRY / PDB]
ModBase P59443.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_188-MON; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00596; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005993; GMP_reduct1.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000235; GMP_reductase; 1.
TIGRFAMs TIGR01305; GMP_reduct_1; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS P59443.
Genome annotation databases
GeneID 1058572; -.
GenomeReviews AE016826_GR; bbp_188.
KEGG bab:bbp188; -.
Phylogenomic databases
HOGENOM P59443; -.
Genome annotation databases
CMR P59443; bbp_188.
Other
ProtoNet P59443.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   351  351     GMP reductase. PRO_0000093734
NP_BIND   108   131  24     NADP (By similarity). 
NP_BIND   216   239  24     NADP (By similarity). 
ACT_SITE   186   186        Thioimidate intermediate (By similarity). 
METAL   181   181        Potassium (via carbonyl oxygen) (By similarity). 
METAL   183   183        Potassium (via carbonyl oxygen) (By similarity). 
Sequence information
Length: 351 AA [This is the length of the unprocessed precursor] Molecular weight: 38564 Da [This is the MW of the unprocessed precursor] CRC64: 67FEEFB53391DD81 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRIEEDIKLG FKDVLIRPKR SILKSRSQVD LTRLFIFKHA QNKWSGIPLI AANMDTVGTF 

        70         80         90        100        110        120 
KMAIALSSFG ILTAIHKYYS YLDWKKFIHT IPGTVVKHIM VSTGMLDEDF VKLKQILSLS 

       130        140        150        160        170        180 
SKLKYICIDV ANGYSEKFVT FLKKVRECYC DKIICAGNVV TGEMVEELIL SGADIVKVGI 

       190        200        210        220        230        240 
GPGSVCTTRA KTAIGYPQLS AVIECSDAAH GLGGQIISDG GCVVSGDIAK AFGGGADFVM 

       250        260        270        280        290        300 
LGGMLAGHKE CEGLIFKENK KRYMIFYGMS SKFAMDRHIG GVARYKTPEG KTVKVLFRGA 

       310        320        330        340        350 
VSETINNILG GLRSTCTYVG AFTLKELTKR TTFIKVSEQE NIIFNNQEVS N 

P59443 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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