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- FUNCTION: Catalyzes the oxidation of various aldopyranoses and disaccharides on carbon-2 to the corresponding 2-keto sugars concomitant with the reduction of O(2) to H(2)O(2). Plays an important role in lignin degradation of wood rot fungi by supplying the essential cosubstrate H(2)O(2) for the ligninolytic peroxidases, lignin peroxidase and manganese-dependent peroxidase. The preferred substrate is D-glucose which is converted to 2-dehydro-D-glucose, an intermediate of a secondary metabolic pathway leading to the antibiotic cortalcerone. Acts also on D-xylose, together with D-glucose the major sugars derived from wood, on L-sorbose, D-galactose and 1,5-anhydroglucitol, a diagnostic marker of diabetes mellitus.
- CATALYTIC ACTIVITY: D-glucose + O2 = 2-dehydro-D-glucose + H2O2.
- COFACTOR: Binds 1 FAD covalently per subunit (By similarity).
- BIOPHYSICOCHEMICAL PROPERTIES:
| pH dependence: |
Optimum pH is 6. Active and stable from pH 3 to 9; | | Temperature dependence: |
Optimum temperature is 30-50 degrees Celsius. Active and thermostable for 30 minutes up to 55 degrees Celsius; | |
- SUBUNIT: Homotetramer (By similarity).
- SUBCELLULAR LOCATION: Periplasm (By similarity). Note=Hyphal periplasmic space (By similarity).
- SIMILARITY: Belongs to the GMC oxidoreductase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 622 AA [This is the length of the unprocessed precursor] |
Molecular weight: 69082 Da [This is the MW of the unprocessed precursor] |
CRC64: 0B616C02014E7C5B [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSASSSDPFH SFAKTSFTSK AAKRATAHSL PPLPGPGDLP PGMNVEYDVA IVGSGPIGCT
70 80 90 100 110 120
YARELVEAGF NVAMFEIGEI DSGLKIGSHK KNTVEYQKNI DKFVNVIQGQ LMPVSVPVNT
130 140 150 160 170 180
MVVDTLSPAS WQASTFFVRN GANPEQDPLR NLSGQAVTRV VGGMSTHWTC ATPRFEKLQR
190 200 210 220 230 240
PLLVKNDSKA DDAEWDRLYK KAESYFKTGT TQFAESIRHN LVLKKLQEEY KGVRDFQQIP
250 260 270 280 290 300
LAATRQSPTF VEWSSAHTVF DLENRPNKDA PKQRFNLFPA VACTNVRRDN ANSEIVGLDV
310 320 330 340 350 360
RDLHGGKSIT IKAKVYILTA GAVHNAQLLA ASGFGQLGRP DPAKPLPSLL PYLGTHITEQ
370 380 390 400 410 420
TLVFCQTVMS TELINSVTAD MTIVGKPGHP DYSVTYTPGN PNNKHPDWWN EKVKKHMMDH
430 440 450 460 470 480
QEDPLPIPFE DPEPQVTTLF QATHPWHTQI HRDAFSYGAV QQSIDSRLIV DWRFFGRTEP
490 500 510 520 530 540
KEENKLWFSD KITDAYNLRQ PTFDFRFPGG REAEDMMTDM CVMSAKIGGF LPGSYPQFME
550 560 570 580 590 600
PGLVLHLGGT HRMGFDEKAD KCCVDTDSRV FGFKNLFLGG CGNIPTAYAA NPTLTAMSLA
610 620
IKSCEYIKKN FEPSPNPVKH HN
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P59097 in FASTA format |
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