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UniProtKB/Swiss-Prot entry P57655

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_BUCAI
Primary accession number P57655
Secondary accession number Q9AQ95
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 47)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: BU599
From
Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [TaxID: 118099] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tokyo 1998;
DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan]
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.";
Nature 407:81-86(2000).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-412.
Wernegreen J.J., Moran N.A.;
"Accelerated evolutionary rates at biosynthetic loci of Buchnera-Uroleucon.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000003; BAB13284.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF217558; AAK01029.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_240398.1; -.
3D structure databases
HSSP Q9HVA2; 1NP3. [HSSP ENTRY / PDB]
ModBase P57655.
Enzyme and pathway databases
BioCyc BSP107806:BU599-MON; -.
Ontologies
GO
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR014359; KetolA_reductoisomerase_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000116; IlvC_gammaproteo; 1.
TIGRFAMs TIGR00465; ilvC; 1.
BLOCKS P57655.
Genome annotation databases
GeneID 1109935; -.
GenomeReviews BA000003_GR; BU599.
KEGG buc:BU599; -.
Phylogenomic databases
HOGENOM P57655; -.
Genome annotation databases
CMR P57655; BU599.
Other
ProtoNet P57655.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   490  490     Ketol-acid reductoisomerase. PRO_0000151286
ACT_SITE   131   131        Potential. 
Sequence information
Length: 490 AA [This is the length of the unprocessed precursor] Molecular weight: 55828 Da [This is the MW of the unprocessed precursor] CRC64: 0C108D0AF1476504 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNYFNTLNFT QKINQINKCR FMKKEEFNKK NDILKNKNIV IVGCGAQGLN QGLNMRDAGL 

        70         80         90        100        110        120 
NISYALKKNS IANKNQSWIN AIENNFKVDD YDALIPDADL VINLTPDKQH HSVIKKLQKL 

       130        140        150        160        170        180 
MKKNAVLGYS HGFNIVEFGE KIRKDITVIM VAPKCPGTEV REEYKRGFGV PTLIAVHHEN 

       190        200        210        220        230        240 
DINKIGLEVA KAWAFSTGGH RAGVLESSFI AEVKSDLMGE QTILCGMLQT ASLLCYEKLI 

       250        260        270        280        290        300 
TEKCNPAYSA KLIQNGWETI TESLKHGGIT LMMDRLSNSS KIRAYKLSKE IKKILSPLFQ 

       310        320        330        340        350        360 
KHMDDIISGE FSNEMMKDWE NQDLKLLNWR YKTKNTSFET APVYNEKIPE QEYYDHGILM 

       370        380        390        400        410        420 
IAILKSGIEL SFEKMIETGI KEESAYYESL HELPLIANTI ARKKLYEMNK VISDTAEYGS 

       430        440        450        460        470        480 
YLFSESAYPI LKEFISTLNK SDLGCALSHQ SVNNIELYRI NQKIQNHPIE IIGCTLRNYM 

       490 
KKMKAITVAK
P57655 in FASTA format

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