NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tokyo 1998;
DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan]
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.";
Nature 407:81-86(2000).

Comments

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
CATALYTIC ACTIVITY: NADH + quinone = NAD⁺ + quinol.
SUBUNIT: Composed of 13 different subunits. Subunits nuoCD, E, F, and G constitute the peripheral sector of the complex (By similarity).
SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000003; BAB12874.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_239988.1; -.

3D structure databases

ModBase

P57254.

Enzyme and pathway databases

BioCyc

BSP107806:BU156-MON; -.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00329; Complex1_30kDa; 1.
PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

ProDom

PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01961; NuoC_fam; 1.
TIGR01962; NuoD; 1.

PROSITE

PS00542; COMPLEX1_30K; FALSE_NEG.
PS00535; COMPLEX1_49K; 1.

BLOCKS

P57254.

Genome annotation databases

GeneID

1109600; -.

GenomeReviews

BA000003_GR; BU156.

KEGG

buc:BU156; -.

Phylogenomic databases

HOGENOM

P57254; -.

Genome annotation databases

CMR

P57254; BU156.

Other

ProtoNet

P57254.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Multifunctional enzyme; NAD; Oxidoreductase; Quinone.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 600`	`600`	`NADH-quinone oxidoreductase subunit C/D.`	`PRO_0000118681`
`REGION`	`1 190`	`190`	`NADH dehydrogenase I subunit C.`
`REGION`	`214 600`	`387`	`NADH dehydrogenase I subunit D.`

Sequence information

Length: 600 AA [This is the length of the unprocessed precursor]

Molecular weight: 69576 Da [This is the MW of the unprocessed precursor]

CRC64: 033AA3AFAC5C567D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIDLMPKKNT FLLKKKYKED SNNSVINNLF DFFGKEFCFH QITLTGFPII WIDKTLLIEV 

        70         80         90        100        110        120 
GKFLYHLSQP YIMLYDLHGV DERIRLHRED LPKADFSVFY HLISIERNSD IMIKVPLLEN 

       130        140        150        160        170        180 
DLILPTFTGL FPNANWYERE TWDMFGIIFN NHPNLTRIIM PSTWKGHPLR KNYSARATEY 

       190        200        210        220        230        240 
EPFFLNEQKE DLEMEGLKFK PELWGMKRKN DNVEFMFLNL GPNHPSAHGA FRIVLQLDGE 

       250        260        270        280        290        300 
NIVDCVPDIG YHHRGAEKMA ERQSWHSYIP YTDRIEYLGG CVNELPYVLA VEKLANISVP 

       310        320        330        340        350        360 
EKAEVIRVMM SELFRINSHL LYISTFIQDV GCMTPVFFAF TDRQKIYDLI EAITGARMHP 

       370        380        390        400        410        420 
AWFRIGGVAN DLPQGWNILL KEFLDWMPKR LKYYINTALK NSILIHRSKG IAEYNKKEAL 

       430        440        450        460        470        480 
QWGVTGAGLR ATGLNFDVRK WRPYSGYQNY TFEVPVGSGI SDCYSRVMIK VEEIYQSLFI 

       490        500        510        520        530        540 
LKQCLCNMPS GPFKSEDSLT TPPSKECVLQ NIETMITHFL QVSWGPVIPE NESFQMIEAT 

       550        560        570        580        590        600 
KGINSYYLIS DGGTMSYRTR IRTPSFPHLQ QIPSVIRGSL ISDLIVYLGS IDFVMSDVDR

P57254 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools