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UniProtKB/Swiss-Prot entry P57093


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PAHX_RAT
Primary accession number P57093
Secondary accession number Q9QY64
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on January 11, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 47)
Name and origin of the protein
Protein name Phytanoyl-CoA dioxygenase, peroxisomal [Precursor]
Synonyms EC 1.14.11.18
Phytanoyl-CoA alpha-hydroxylase
PhyH
Phytanic acid oxidase
Gene name
Name: Phyh
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar;
TISSUE=Liver;
PubMed=10588950 [NCBI, ExPASy, EBI, Israel, Japan]
Jansen G.A., Ofman R., Denis S., Ferdinandusse S., Hogenhout E.M., Jakobs C., Wanders R.J.A.;
"Phytanoyl-CoA hydroxylase from rat liver: protein purification and cDNA cloning with implications for the subcellular localization of phytanic acid alpha-oxidation.";
J. Lipid Res. 40:2244-2254(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 31-50 AND 232-241.
DOI=10.1038/ng1097-190; PubMed=9326940 [NCBI, ExPASy, EBI, Israel, Japan]
Jansen G.A., Ofman R., Ferdinandusse S., Ijlst L., Muijsers A.O., Skjeldal O.H., Stokke O., Jakobs C., Besley G.T.N., Wraith J.E., Wanders R.J.A.;
"Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene.";
Nat. Genet. 17:190-193(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF121345; AAF15971.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC086573; AAH86573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446126.1; -.
UniGene Rn.7279
3D structure databases
SMR P57093; 44-322.
ModBase P57093.
Organism-specific databases
RGD 620317; Phyh.
Gene expression databases
ArrayExpress P57093; -.
GermOnline ENSRNOG00000018044; Rattus norvegicus.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from direct assay from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR008775; Phytyl_CoA_dOase.
Graphical view of domain structure.
Pfam PF05721; PhyH; 1.
Pfam graphical view of domain structure.
BLOCKS P57093.
Genome annotation databases
Ensembl ENSRNOG00000018044; Rattus norvegicus. [Contig view]
GeneID 114209; -.
KEGG rno:114209; -.
Phylogenomic databases
HOVERGEN P57093; -.
Other
ProtoNet P57093.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Iron; Oxidoreductase; Peroxisome; Transit peptide; Vitamin C.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    30  30     Peroxisome. 
CHAIN   31   338  308     Phytanoyl-CoA dioxygenase, peroxisomal. PRO_0000024055
CONFLICT   241   241        P -> Q (in Ref. 3; AA sequence). 
Sequence information
Length: 338 AA [This is the length of the unprocessed precursor] Molecular weight: 38588 Da [This is the MW of the unprocessed precursor] CRC64: EA0E93AF7D47880E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDYTRAGARL QVLLGHLGRP SALQIVAHPV SGPASPANFC PEQFQYTLDN NVLSLEQRKF 

        70         80         90        100        110        120 
YEENGFLVIK NLVSDDDIQR FRAEFERICR KEVKPPGMTV MKDVAIAKQG YAPSERVVTK 

       130        140        150        160        170        180 
IQDFQQNEEL FRYCALPQIV KYVECFTGPN IMAMHTMLIN KPPDSGKKTS RHPLHQDLHF 

       190        200        210        220        230        240 
FPFRPSNLIV CAWTAMEHID RNNGCLVVLP GTHKGPLKPH DYPKWEGGVN KMYHGIQDYD 

       250        260        270        280        290        300 
PDSPRVHLVM EKGDTVFFHP LLIHGSGRNR TQGFRKAISC HYGSSDCKYI SVKGTSQENI 

       310        320        330 
AREVIEIAEK RYGVQGALDF EDTWKFRCRL VKGERINL 

P57093 in FASTA format

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