[1]	X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). TISSUE=Liver; PubMed=9792097 [NCBI, ExPASy, EBI, Israel, Japan] Johansson K., El-Ahmad M., Ramaswamy S., Hjelmqvist L., Joernvall H., Eklund H.; "Structure of betaine aldehyde dehydrogenase at 2.1-A resolution."; Protein Sci. 7:2106-2117(1998).

Comments

CATALYTIC ACTIVITY: Betaine aldehyde + NAD⁺ + H₂O = betaine + NADH.
CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1 .
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

PDB

1A4S; X-ray; 2.10 A; A/B/C/D=1-503.	[ExPASy / RCSB / EBI]
1BPW; X-ray; 2.80 A; A/B/C/D=1-503.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1A4S; -.
1BPW; -.

ModBase

P56533.

Protein-protein interaction databases

DIP

DIP:2908N; -.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

P56533.

Phylogenomic databases

HOVERGEN

P56533; -.

Other

P56533; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Cytoplasm; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 503`	`503`	`Betaine aldehyde dehydrogenase.`	`PRO_0000056532`
`NP_BIND`	`241 246`	`6`	`NAD (By similarity).`
`ACT_SITE`	`263 263`		`Proton acceptor.`
`ACT_SITE`	`297 297`		`Nucleophile.`
`SITE`	`166 166`	`1`	`Transition state stabilizer.`
`HELIX`	`2 5`	`4`
`HELIX`	`7 9`	`3`
`TURN`	`12 14`	`3`
`STRAND`	`22 24`	`3`
`STRAND`	`27 29`	`3`
`STRAND`	`38 41`	`4`
`TURN`	`43 45`	`3`
`STRAND`	`48 52`	`5`
`HELIX`	`57 74`	`18`
`HELIX`	`79 95`	`17`
`HELIX`	`97 108`	`12`
`HELIX`	`112 132`	`21`
`HELIX`	`133 135`	`3`
`STRAND`	`138 142`	`5`
`HELIX`	`144 146`	`3`
`STRAND`	`148 155`	`8`
`STRAND`	`157 162`	`6`
`STRAND`	`165 167`	`3`
`HELIX`	`168 181`	`14`
`STRAND`	`185 189`	`5`
`HELIX`	`196 207`	`12`
`STRAND`	`214 217`	`4`
`HELIX`	`222 230`	`9`
`STRAND`	`236 241`	`6`
`HELIX`	`243 254`	`12`
`TURN`	`255 257`	`3`
`STRAND`	`259 263`	`5`
`STRAND`	`269 272`	`4`
`HELIX`	`278 287`	`10`
`HELIX`	`291 294`	`4`
`STRAND`	`302 306`	`5`
`HELIX`	`307 309`	`3`
`HELIX`	`310 322`	`13`
`HELIX`	`342 358`	`17`
`STRAND`	`361 364`	`4`
`HELIX`	`374 376`	`3`
`STRAND`	`385 389`	`5`
`HELIX`	`395 398`	`4`
`STRAND`	`403 411`	`9`
`HELIX`	`414 422`	`9`
`STRAND`	`428 433`	`6`
`HELIX`	`437 446`	`10`
`STRAND`	`449 455`	`7`
`HELIX`	`470 472`	`3`
`HELIX`	`481 485`	`5`
`STRAND`	`486 494`	`9`

Sequence information

Length: 503 AA [This is the length of the unprocessed precursor]

Molecular weight: 54368 Da [This is the MW of the unprocessed precursor]

CRC64: 1CB2FB92FA89E577 [This is a checksum on the sequence]

        10         20         30         40         50         60 
AQLVDSMPSA STGSVVVTDD LNYWGGRRIK SKDGATTEPV FEPATGRVLC QMVPCGAEEV 

        70         80         90        100        110        120 
DQAVQSAQAA YLKWSKMAGI ERSRVMLEAA RIIRERRDNI AKLEVINNGK TITEAEYDID 

       130        140        150        160        170        180 
AAWQCIEYYA GLAPTLSGQH IQLPGGAFAY TRREPLGVCA GILAWNYPFM IAAWKCAPAL 

       190        200        210        220        230        240 
ACGNAVVFKP SPMTPVTGVI LAEIFHEAGV PVGLVNVVQG GAETGSLLCH HPNVAKVSFT 

       250        260        270        280        290        300 
GSVPTGKKVM EMSAKTVKHV TLELGGKSPL LIFKDCELEN AVRGALMANF LTQGQVCTNG 

       310        320        330        340        350        360 
TRVFVQREIM PQFLEEVVKR TKAIVVGDPL LTETRMGGLI SKPQLDKVLG FVAQAKKEGA 

       370        380        390        400        410        420 
RVLCGGEPLT PSDPKLKNGY FMSPCVLDNC RDDMTCVKEE IFGPVMSVLP FDTEEEVLQR 

       430        440        450        460        470        480 
ANNTTFGLAS GVFTRDISRA HRVAANLEAG TCYINTYSIS PVEVPFGGYK MSGFGRENGQ 

       490        500 
ATVDYYSQLK TVIVEMGDVD SLF

P56533 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools