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UniProtKB/Swiss-Prot entry P56201

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PE_RABIT
Primary accession number P56201
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name GDH/6PGL endoplasmic bifunctional protein
Synonyms None
Includes Glucose 1-dehydrogenase
     (EC 1.1.1.47)
     (Hexose-6-phosphate dehydrogenase)
6-phosphogluconolactonase
     (6PGL)
     (EC 3.1.1.31)
Gene name
Name: H6PD
Synonyms: GDH
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE.
STRAIN=New Zealand white;
TISSUE=Liver;
PubMed=8506377 [NCBI, ExPASy, EBI, Israel, Japan]
Ozols J.;
"Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase.";
Proc. Natl. Acad. Sci. U.S.A. 90:5302-5306(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase P56201.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (inferred from electronic annotation from UniProtKB-KW).
GO:0005788; Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
GO:0017057; Molecular function: 6-phosphogluconolactonase activity (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0047936; Molecular function: glucose 1-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006098; Biological process: pentose-phosphate shunt (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
IPR005900; Phosphogluconlac.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01198; pgl; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
Genome annotation databases
Ensembl ENSOCUG00000000798; Oryctolagus cuniculus. [Contig view]
Phylogenomic databases
HOVERGEN P56201; -.
Other
ProtoNet P56201.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Direct protein sequencing; Endoplasmic reticulum; Glucose metabolism; Glycoprotein; Hydrolase; Multifunctional enzyme; NAD; NADP; Oxidoreductase; Phosphoprotein; Pyrrolidone carboxylic acid.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   763  763     GDH/6PGL endoplasmic bifunctional protein. PRO_0000068139
REGION   1   507  507     Glucose 1-dehydrogenase. 
REGION   508   521  14     Linker. 
REGION   522   763  242     6-phosphogluconolactonase. 
ACT_SITE   248   248        Proton acceptor (By similarity). 
BINDING   15    15        NADP (By similarity). 
BINDING   47    47        NADP (By similarity). 
BINDING   185   185        Substrate (By similarity). 
BINDING   189   189        Substrate (By similarity). 
MOD_RES   1     1        Pyrrolidone carboxylic acid. 
MOD_RES   297   297        Phosphotyrosine (By similarity). 
CARBOHYD   138   138        N-linked (GlcNAc...). 
CARBOHYD   263   263        N-linked (GlcNAc...). 
VARIANT   69    69  1     R -> K. 
VARIANT   75    75  1     L -> R. 
Sequence information
Length: 763 AA [This is the length of the unprocessed precursor] Molecular weight: 85285 Da [This is the MW of the unprocessed precursor] CRC64: 2A4E1039062E8672 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
QELQGHVSVI LLGATGDLAK KYLWQGLFQL FLDEAGKGHS FSFHGAALTA PKQGQELMAK 

        70         80         90        100        110        120 
ALESLSCPRD MAPSLCAELQ AQFLRLSRYR QLKTAEDYQA LGRDIEAQVQ QEGLREAGRM 

       130        140        150        160        170        180 
FYFSVPPFAY ADIARNINSS CRPGPGAWLR VVLEKPFGHD HLSAQQLATE LGSFFQEEEM 

       190        200        210        220        230        240 
YRVDHYLGKQ AVAQILPFRD QNRRALDSLW NRHHVERVEI IMKETVDAEG RTSFYEEYGV 

       250        260        270        280        290        300 
IRDTLQNHLT EILTLVAMEL PANVSCSEAV LRHKLQAFRA LRRLQRGSAV VGQYQTYSEQ 

       310        320        330        340        350        360 
VRGELRKPAG SPSLTPTFAG VLVHVDNLRM EGVPFILMSG KALDERVGYV RVLFKNQAFC 

       370        380        390        400        410        420 
AQSEKHWAPA QSRCLPRCII FYIGHGELGH PAVVVSRNLF RPFLPAQSWR EVEDRPGLQL 

       430        440        450        460        470        480 
FGRPLSDFYA FSPVKERDAY SILLSHIFHA RKESFVPTEH LLASWVFWTP LLESLAREVP 

       490        500        510        520        530        540 
RLYPGGADSG RLLDFEFSGS HLSFSLGQPE QLVPGPGSTP RPSDFQVLGA KYRESPLISA 

       550        560        570        580        590        600 
WPDELISKLA SDIEAAAVQA VRRVGTFHLA LSGGSSPIAL FQQLASGHYG FPVPLSDPES 

       610        620        630        640        650        660 
NFQGLQAHLL QHVRVPYYNI HPMPVNLHQR LCAEEDRGAQ AAYASEISAL VTWCSFDEVL 

       670        680        690        700        710        720 
QGMGTDGHTA SLFPQSPTGL DGEQLVVLTE SPSRPHQQRR MSLSLPLINR AKKVAVLVMG 

       730        740        750        760 
RTKRDITLLV SRVGREPKNW PISGVLPTSG QLVWYMDYEA FLG
P56201 in FASTA format

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