ID   GLI1_CHICK              Reviewed;         556 AA.
AC   P55878;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-NOV-2008, entry version 49.
DE   RecName: Full=Zinc finger protein GLI1;
DE            Short=GLI;
DE   Flags: Fragment;
GN   Name=GLI1; Synonyms=GLI;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97105842; PubMed=8948590; DOI=10.1006/dbio.1996.0300;
RA   Marigo V., Johnson R.L., Vortkamp A., Tabin C.J.;
RT   "Sonic hedgehog differentially regulates expression of GLI and GLI3
RT   during limb development.";
RL   Dev. Biol. 180:273-283(1996).
CC   -!- FUNCTION: May regulate the transcription of specific genes during
CC       normal development. May play a role in craniofacial development
CC       and digital development, as well as development of the central
CC       nervous system and gastrointestinal tract. Mediates SHH signaling
CC       and thus cell proliferation and differentiation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
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DR   EMBL; U60762; AAB51659.1; -; mRNA.
DR   UniGene; Gga.614; -.
DR   HSSP; P08151; 2GLI.
DR   Ensembl; ENSGALG00000014639; Gallus gallus.
DR   HOGENOM; P55878; -.
DR   HOVERGEN; P55878; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   ProDom; PD000003; Znf_C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Nucleus; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   >556       Zinc finger protein GLI1.
FT                                /FTId=PRO_0000047199.
FT   ZN_FING     247    272       C2H2-type 1.
FT   ZN_FING     280    307       C2H2-type 2.
FT   ZN_FING     313    337       C2H2-type 3.
FT   ZN_FING     343    368       C2H2-type 4.
FT   ZN_FING     374    399       C2H2-type 5.
FT   NON_TER     556    556
SQ   SEQUENCE   556 AA;  60216 MW;  722D2AA5A1CA4D98 CRC64;
     MFNPVTPQAR PYAEHCCPRP LHGASAGTPG LQGLDFPVCH QPNLASSHHG YGLVPGTEHP
     GGAADGSRFS TPRGAGKLGK KRALSISPLS DSSVDLQTVI RTSPNSLVAF INSRCASAGG
     SYGHLSISTI SPSLGYQNPP GQQKGQGQLF SHTPPLPPCS SHETLSSRPG LLHPTPARGT
     IKHCQQLKLE RSLSSPLTAK YPEEKSEGDI SSPASTGTQD PLLGMLSVRD DLEKEDGKPE
     SETIYETNCY WDGCAKEFDT QEQLVHHINN EHIHGEKKEF VCHWAACSRE QRPFKAQYML
     VVHMRRHTGE KPHKCTFEGC NKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR
     AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKHR GSVVPGHALP
     ASAAPQDMKQ EKNTNGPAEI RKDDGKLLVP DLVSKPQPSP GGQSSCSSDR SPLGSTTNND
     SGVEMTGNTG GSYEDLVHAG GCGARGSHGH LGADGLQKLE NLRIDKLKQM RKPSTKGLNL
     PAIPEPVCRR CVRVCV
//