[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1006/dbio.1996.0300; PubMed=8948590 [NCBI, ExPASy, EBI, Israel, Japan] Marigo V., Johnson R.L., Vortkamp A., Tabin C.J.; "Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development."; Dev. Biol. 180:273-283(1996).

Comments

FUNCTION: May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U60762; AAB51659.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Gga.614

3D structure databases

HSSP

P08151; 2GLI. [HSSP ENTRY / PDB]

ModBase

P55878.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.

Pfam

PF00096; zf-C2H2; 4.
Pfam graphical view of domain structure.

ProDom

PD000003; Znf_C2H2; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00355; ZnF_C2H2; 5.
SMART graphical view of domain structure.

PROSITE

PS00028; ZINC_FINGER_C2H2_1; 4.
PS50157; ZINC_FINGER_C2H2_2; 5.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P55878.

Genome annotation databases

Ensembl

ENSGALG00000014639; Gallus gallus. [Contig view]

Phylogenomic databases

HOGENOM

P55878; -.

HOVERGEN

P55878; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >556`	`>556`	`Zinc finger protein GLI1.`	`PRO_0000047199`
`ZN_FING`	`247 272`	`26`	`C2H2-type 1.`
`ZN_FING`	`280 307`	`28`	`C2H2-type 2.`
`ZN_FING`	`313 337`	`25`	`C2H2-type 3.`
`ZN_FING`	`343 368`	`26`	`C2H2-type 4.`
`ZN_FING`	`374 399`	`26`	`C2H2-type 5.`
`NON_TER`	`556 556`

Sequence information

Length: 556 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 60216 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 722D2AA5A1CA4D98 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFNPVTPQAR PYAEHCCPRP LHGASAGTPG LQGLDFPVCH QPNLASSHHG YGLVPGTEHP 

        70         80         90        100        110        120 
GGAADGSRFS TPRGAGKLGK KRALSISPLS DSSVDLQTVI RTSPNSLVAF INSRCASAGG 

       130        140        150        160        170        180 
SYGHLSISTI SPSLGYQNPP GQQKGQGQLF SHTPPLPPCS SHETLSSRPG LLHPTPARGT 

       190        200        210        220        230        240 
IKHCQQLKLE RSLSSPLTAK YPEEKSEGDI SSPASTGTQD PLLGMLSVRD DLEKEDGKPE 

       250        260        270        280        290        300 
SETIYETNCY WDGCAKEFDT QEQLVHHINN EHIHGEKKEF VCHWAACSRE QRPFKAQYML 

       310        320        330        340        350        360 
VVHMRRHTGE KPHKCTFEGC NKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR 

       370        380        390        400        410        420 
AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKHR GSVVPGHALP 

       430        440        450        460        470        480 
ASAAPQDMKQ EKNTNGPAEI RKDDGKLLVP DLVSKPQPSP GGQSSCSSDR SPLGSTTNND 

       490        500        510        520        530        540 
SGVEMTGNTG GSYEDLVHAG GCGARGSHGH LGADGLQKLE NLRIDKLKQM RKPSTKGLNL 

       550 
PAIPEPVCRR CVRVCV

P55878 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools