FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
SUBCELLULAR LOCATION: Peroxisome (By similarity).
SIMILARITY: Belongs to the catalase family.

Copyright

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Cross-references

Sequence databases

EMBL

Z54346; CAA91159.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P15202; 1A4E. [HSSP ENTRY / PDB]

ModBase

P55304.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; FALSE_NEG.
PS00438; CATALASE_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase; Peroxisome.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 479`	`479`	`Catalase A.`	`PRO_0000084917`
`ACT_SITE`	`63 63`		`By similarity.`
`METAL`	`346 346`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 479 AA [This is the length of the unprocessed precursor]

Molecular weight: 53686 Da [This is the MW of the unprocessed precursor]

CRC64: B8CD0D8391A244CC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAQTNGVLQE PAITTMNGAP VLKPASTQRI GNQLRATLLL QDINLLELIQ HITHERIPER 

        70         80         90        100        110        120 
VVHARGTSAH GYFEVTDDIS DVTSAAFLNR VGKQTDIFCR FSTVAGRAES AETVRDTRGF 

       130        140        150        160        170        180 
AFKMFTEEGN LDWLFLSTPV FPIRDGAKFP SFTHATKKNP RSGLPDHKAF WDYFTHNQEG 

       190        200        210        220        230        240 
IHFLMFLFSD RATPVDFQHA DIFSINTYKF TKSDGSFTYV KIHLKTNQGV KNFTQDEANQ 

       250        260        270        280        290        300 
KAGVDPDFQT RSLYEDIENQ KYPTWDVFAQ IIDPVKAENY HINIFDATKT FPFSEFPLRK 

       310        320        330        340        350        360 
FGKITLNRNV DNFFAEQEQS AFSPTNLVPG WALTPDPIIQ TRALAYADTQ RYRLGANFVQ 

       370        380        390        400        410        420 
LPVNAPYKKP FTPLIRDGAA TVNGNLGGTP NYFPSSFYNV GAATQYAQPD EEQFQGTVVN 

       430        440        450        460        470 
FESEVVDADY VQPRIFWEKT LAEEPGQQDN LISNVAGHLS AVTGDKGLGS STSGLCNVR

P55304 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools