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UniProtKB/Swiss-Prot entry P55249

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LX12E_MOUSE
Primary accession number P55249
Secondary accession number Q91YW6
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 72)
Name and origin of the protein
Protein name Arachidonate 12-lipoxygenase, epidermal-type
Synonyms 12-LOX
EC 1.13.11.31
Gene name
Name: Alox12e
Synonyms: Alox12-ps2, Aloxe
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X 129/Sv;
TISSUE=Epidermis;
DOI=10.1074/jbc.271.38.23338; PubMed=8798535 [NCBI, ExPASy, EBI, Israel, Japan]
Funk C.D., Keeney D.S., Oliw E.H., Boeglin W.E., Brash A.R.;
"Functional expression and cellular localization of a mouse epidermal lipoxygenase.";
J. Biol. Chem. 271:23338-23344(1996).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
TISSUE=Epidermis;
DOI=10.1016/0005-2760(95)00158-9; PubMed=7492614 [NCBI, ExPASy, EBI, Israel, Japan]
van Dijk K.W., Steketee K., Havekes L., Frants R., Hofker M.;
"Genomic and cDNA cloning of a novel mouse lipoxygenase gene.";
Biochim. Biophys. Acta 1259:4-8(1995).
[3]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=NMRI;
TISSUE=Skin;
DOI=10.1016/S0014-5793(96)01517-7; PubMed=9037187 [NCBI, ExPASy, EBI, Israel, Japan]
Kinzig A., Fuerstenberger G., Mueller F., Vogel S., Mueller-Decker K., Mincheva A., Lichter P., Marks F., Krieg P.;
"Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform.";
FEBS Lett. 402:162-166(1997).
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-260; LEU-453 AND SER-617.
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U39200; AAC52869.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U24181; AAC52324.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X99252; CAA67625.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013751; AAH13751.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051047; AAH51047.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_663717.1; -.
UniGene Mm.274093
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
ModBase P55249.
Organism-specific databases
MGI MGI:1274790; Alox12e.
Gene expression databases
ArrayExpress P55249; -.
CleanEx MM_ALOX12E; -.
GermOnline ENSMUSG00000018907; Mus musculus.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P55249.
Genome annotation databases
Ensembl ENSMUSG00000018907; Mus musculus. [Contig view]
GeneID 11685; -.
KEGG mmu:11685; -.
Phylogenomic databases
HOGENOM P55249; -.
HOVERGEN P55249; -.
Other
SOURCE Alox12e; Mus musculus.
ProtoNet P55249.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   662  662     Arachidonate 12-lipoxygenase, epidermal-type. PRO_0000220688
DOMAIN   2   114  113     PLAT. 
DOMAIN   115   662  548     Lipoxygenase. 
METAL   360   360        Iron; catalytic (By similarity). 
METAL   365   365        Iron; catalytic (By similarity). 
METAL   540   540        Iron; catalytic (By similarity). 
METAL   662   662        Iron; via carboxylate; catalytic (By similarity). 
VARIANT   260   260  1     V -> L (in strain:FVB/N). 
VARIANT   453   453  1     V -> L (in strain:FVB/N). 
VARIANT   617   617  1     P -> S (in strain:FVB/N). 
CONFLICT   619   619        P -> A (in Ref. 2; AAC52324). 
Sequence information
Length: 662 AA [This is the length of the unprocessed precursor] Molecular weight: 75456 Da [This is the MW of the unprocessed precursor] CRC64: D67768415EE988F7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVKYKILVAT GDSVFAGSAN LVHLWLVGEH GEADLGKQLR PLLGRKTELE VDVPLHLGRL 

        70         80         90        100        110        120 
LAVKLRKQKG LLDSDWFCKS ITVQGPGTQG EAFFPCYSWV QGKETICLTE GTALKVTDDT 

       130        140        150        160        170        180 
QNLFRKYREQ ELENRRNVYR WGSWKEGLIL PIAGSTERDL PRNQRFMKDK DLDFSLSLVK 

       190        200        210        220        230        240 
ELKNFAIKGT LDFVSRVQKL EDYQKVFPHT KTALPERVRG SWKEDALFGY QFLNGANPML 

       250        260        270        280        290        300 
LRRSMRLPAR LVLPPGMEDV QTQLEKELKA GSLFEVDFSL LDGVKPNIII FKQQYVTAPL 

       310        320        330        340        350        360 
VMLKLQPDGR LLPMVIQLQP PRHGCPPPLL FLPSDPPMAW LLAKIWVRSS DFQLHQLQSH 

       370        380        390        400        410        420 
LLRGHLMAEV ISVATMRSLP SLHPIYKLLA PHFRYTMEIN TLARNNLVSE WGIFDLVVST 

       430        440        450        460        470        480 
GSGGHVDILQ RATSCLTYRS FCPPDDLADR GLVGVKSSLY AQDALRLWEI ISRYVERMVE 

       490        500        510        520        530        540 
LFYRSDTDVK EDPELQVWCR EVTEVGLLGA QDRGFPLSLE SRAELCRFVA MCIFTCTGQH 

       550        560        570        580        590        600 
ASTHLGQLDW YAWIPNGPCT MRKPPPISKD VTERDIVDSL PCLQQARMQI TVTKFLGRRQ 

       610        620        630        640        650        660 
PVMVALGQHK EEYFSGPRPR DVLKQFQEEL AIMDKEIEVR NASLDLPYEY LRPSLVENSV 


TI
P55249 in FASTA format

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