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- FUNCTION: The EGF receptor mediates the biological signal of EGF, and also of TGF-alpha, amphiregulin, heparin-binding EGF, GP30 and vaccinia virus growth factor.
- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- SUBUNIT: Binds RIPK1. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1 and MUC1 (By similarity).
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- TISSUE SPECIFICITY: Hypothalamus.
- DEVELOPMENTAL STAGE: Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months).
- PTM: Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur (By similarity).
- MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
- SIMILARITY: Contains 1 protein kinase domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 85 AA [This is the length of the partial sequence of the unprocessed precursor] |
Molecular weight: 9866 Da [This is the MW of the partial sequence of the unprocessed precursor] |
CRC64: D812DF47C23B3C18 [This is a checksum on the sequence] |
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10 20 30 40 50 60
HQSDVWSYGV TVWELMTFGS KPYDGIPASE ISSILEKGER LPQPPICTID VYMIMVKCWM
70 80
IDADSRPKFR ELIIEFSKMA RDPQR
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P55245 in FASTA format |
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