NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Ssp. Japonicus;
TISSUE=Testis;
PubMed=1292011 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto H., Kudo T., Masuko N., Miura H., Sato S., Tanaka M., Tanaka S., Takeuchi S., Shibahara S., Takeuchi T.;
"Phylogeny of regulatory regions of vertebrate tyrosinase genes.";
Pigment Cell Res. 5:284-294(1992).

Comments

FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O₂ = L-dopa + dopaquinone + H₂O.
COFACTOR: Binds 2 copper ions per subunit.
SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the tyrosinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S56789; AAB25511.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P55026.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0033162;	Cellular component: melanosome membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005507;	Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004503;	Molecular function: monophenol monooxygenase activity (inferred from electronic annotation from EC).
GO:0006583;	Biological process: melanin biosynthetic process from tyrosine (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR008922; Di-copper_centre.
IPR002227; Tyrosinase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.1280.10; Di-copper_centre; 1.

Pfam

PF00264; Tyrosinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00092; TYROSINASE.

PROSITE

PS00497; TYROSINASE_1; 1.
PS00498; TYROSINASE_2; PARTIAL.

Phylogenomic databases

HOVERGEN

P55026; -.

Other

ProtoNet

P55026.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Glycoprotein; Melanin biosynthesis; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Signal; Transmembrane.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`CHAIN`	`19 >273`	`>255`	`Tyrosinase.`	`PRO_0000035885`
`METAL`	`180 180`		`Copper A (By similarity).`
`METAL`	`202 202`		`Copper A (By similarity).`
`METAL`	`211 211`		`Copper A (By similarity).`
`CARBOHYD`	`86 86`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`169 169`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`230 230`		`N-linked (GlcNAc...) (Potential).`
`NON_TER`	`273 273`

Sequence information

Length: 273 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 31136 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 9365C76EDB26A625 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCLLALGFLL GILQPASGQF PRACASSESL LRKECCPLWA GDGSPCGELS GRGSCQEILL 

        70         80         90        100        110        120 
SRAPLGPQFP FTGVDDREDW PAVFYNRTCQ CNSNFMGFNC GECRFGFSGP NCAERRMRMR 

       130        140        150        160        170        180 
RSIFQLSTRE KNKFLAYLNL AKHTPSQDYV IATGTYAQMN NGLTPMFRNI SVYDLFVWMH 

       190        200        210        220        230        240 
YYVSRDTLLG DASVWRDIDF AHEAPGFLPW HRLFLVLWEH EIQKITGDEN FTIPYWDWRD 

       250        260        270 
AEGCDVCTDE LMGDRHPTNP QLLSPASFFS SWQ

P55026 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools