[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 14077 / CBS 700.72 / DSM 40480 / IFO 13399; Wehmeier U.F., Brass N., Roessler C., Piepersberg W.; Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O₂ = L-dopa + dopaquinone + H₂O.
COFACTOR: Binds 2 copper ions per subunit (By similarity).
SIMILARITY: Belongs to the tyrosinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X95705; CAA65005.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

O61363; 1JS8. [HSSP ENTRY / PDB]

ModBase

P55022.

Ontologies

GO:0005507;	Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004503;	Molecular function: monophenol monooxygenase activity (inferred from electronic annotation from EC).
GO:0006583;	Biological process: melanin biosynthetic process from tyrosine (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR008922; Di-copper_centre.
IPR002227; Tyrosinase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.1280.10; Di-copper_centre; 1.

Pfam

PF00264; Tyrosinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00092; TYROSINASE.

PROSITE

PS00497; TYROSINASE_1; 1.
PS00498; TYROSINASE_2; FALSE_NEG.

Other

ProtoNet

P55022.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Melanin biosynthesis; Metal-binding; Monooxygenase; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 276`	`275`	`Tyrosinase.`	`PRO_0000186736`
`METAL`	`38 38`		`Copper A (By similarity).`
`METAL`	`56 56`		`Copper A (By similarity).`
`METAL`	`66 66`		`Copper A (By similarity).`
`METAL`	`193 193`		`Copper B (By similarity).`
`METAL`	`197 197`		`Copper B (By similarity).`
`METAL`	`219 219`		`Copper B (By similarity).`

Sequence information

Length: 276 AA [This is the length of the unprocessed precursor]

Molecular weight: 31310 Da [This is the MW of the unprocessed precursor]

CRC64: CE0D48B0D3AA5144 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTVRKNQAAL TADEKRRFVA AVLELKRNGR YDEFVRTHNE FIMSDTRTGR RGGPGHRLPL 

        70         80         90        100        110        120 
PFLPWHRRFL LDFEQALQSV DSSVALPYWD WSTDRTVRAS LWAPDFLGGT GRSSDGRVMD 

       130        140        150        160        170        180 
GPFAASTGNW PVNVRVDGRT FLRRSLGTGV RELPTRAEVD SVLSMATYDM APYNSASDGF 

       190        200        210        220        230        240 
RNHLEGWRGV NLHNRVHVWV GGQMATGVSP NDPVFWLHHA YNRQLWAEWQ RRHPGAGYVP 

       250        260        270 
TGGTPDVVDL NDTMKPWNDV RPADLLTHTA HYTFDV

P55022 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools