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UniProtKB/Swiss-Prot entry P54889

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CS_CAEEL
Primary accession number P54889
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Probable delta-1-pyrroline-5-carboxylate synthetase
Synonym P5CS
Includes Glutamate 5-kinase
     (GK)
     (EC 2.7.2.11)
     (Gamma-glutamyl kinase)
Gamma-glutamyl phosphate reductase
     (GPR)
     (EC 1.2.1.41)
     (Glutamate-5-semialdehyde dehydrogenase)
     (Glutamyl-gamma-semialdehyde dehydrogenase)
Gene name
ORFNames: T22H6.2
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z50797; CAA90672.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T25140; T25140.
RefSeq NP_510133.1; -.
UniGene Cel.17267
3D structure databases
HSSP Q9WYC9; 1O20. [HSSP ENTRY / PDB]
ModBase P54889.
Organism-specific databases
WormBase WBGene00011938; T22H6.2.
WormPep T22H6.2; CE03697. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P54889; -.
Family and domain databases
InterPro IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR000965; Gglut_pp_reduct.
IPR001057; Glu_5kinase.
IPR005766; P5_carboxy_syn.
IPR005715; ProB.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
Pfam PF00696; AA_kinase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036429; P5C_syn; 1.
PRINTS PR00474; GLU5KINASE.
TIGRFAMs TIGR01092; P5CS; 1.
TIGR00407; proA; 1.
TIGR01027; proB; 1.
PROSITE PS00902; GLUTAMATE_5_KINASE; 1.
PS01223; PROA; 1.
BLOCKS P54889.
Genome annotation databases
Ensembl T22H6.2; Caenorhabditis elegans. [Contig view]
GeneID 181417; -.
Other
ProtoNet P54889.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; NADP; Oxidoreductase; Proline biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   800  800     Probable delta-1-pyrroline-5-carboxylate synthetase. PRO_0000109771
REGION   1   352  352     Glutamate 5-kinase. 
REGION   353   800  448     Gamma-glutamyl phosphate reductase. 
Sequence information
Length: 800 AA [This is the length of the unprocessed precursor] Molecular weight: 86527 Da [This is the MW of the unprocessed precursor] CRC64: 39223F4973368F00 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFRATRCLRL PLRNSHINIL RPTQTELIKT RSSALAPYEK VSPITAVGAT PVGVGNGNYC 

        70         80         90        100        110        120 
TKTRQKHPLI NTRNDLKKAQ RVVVKLGSAV ITREDECGLA LGRLASIVEQ VSELQQSGRQ 

       130        140        150        160        170        180 
MLIVSSGAVA FGRQKLRQEL VMSMSMRQTL RGPSGMTADK RACAASGMPG LMSLYEQLFQ 

       190        200        210        220        230        240 
QYGITVAQVL LTKPDIDDDQ RRKNLQATIE SLLSLNIIPI VNANDAVAPD PKLNMHISDN 

       250        260        270        280        290        300 
DSLAARLSAE IEAELLIILS NVNGVYTGPP DLEGSRLLYT YVPSENSGVT FGANSKFGTG 

       310        320        330        340        350        360 
GMESKVTACV NALNNGVTTV ITNGLAQDAI TDAVAGKKIG TMFCNTKGYE GPPIEEVAEK 

       370        380        390        400        410        420 
CRDAGRQLAA LSNKERGAMV RHLAALLVDK EKYIIEANQT DLANAKSAGL DPQLLNRLKM 

       430        440        450        460        470        480 
TPEKIQDLHA GLNTIADSAE TLVGRVLKKV KISEGLFLEQ VTVPIGSLMV IFESRPDCLP 

       490        500        510        520        530        540 
QVASLAMASG NALLLKGGKE AEESNKALHA LVQEALGTHG FEMRDAVTLV RSREDVADLL 

       550        560        570        580        590        600 
QLKDLIDLII PRGSSDLVRS MQEKSKGIPV LGHAEGVWHV YIDKDCDEQK AIQIVRDSKC 

       610        620        630        640        650        660 
DYPSACNAAE TILIHKDLAT APFFDSLCSM FKAEGVKLHA GPKLAALLKF APPPAESMSF 

       670        680        690        700        710        720 
EYGSLECTLE VVDNVEEAVA HIIRYGSGHT ESIITENTNT AEHFLKHVDS ACAFHNASTR 

       730        740        750        760        770        780 
FADGYRFGLG AEVGISTGRI HARGPVGVEG LLTTKWLLRG EGHLVEDFKN GKYSYLHENL 

       790        800 
NPSEVYRALD AAGELKKATA
P54889 in FASTA format

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