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UniProtKB/Swiss-Prot entry P54887


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CS1_ARATH
Primary accession number P54887
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Delta-1-pyrroline-5-carboxylate synthetase A
Synonym P5CS A
Includes Glutamate 5-kinase
     (GK)
     (EC 2.7.2.11)
     (Gamma-glutamyl kinase)
Gamma-glutamyl phosphate reductase
     (GPR)
     (EC 1.2.1.41)
     (Glutamate-5-semialdehyde dehydrogenase)
     (Glutamyl-gamma-semialdehyde dehydrogenase)
Gene name
Name: P5CSA
Synonyms: P5CS1
OrderedLocusNames: At2g39800
ORFNames: T5I7.10
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=cv. Columbia;
DOI=10.1016/0014-5793(95)00935-3; PubMed=7556633 [NCBI, ExPASy, EBI, Israel, Japan]
Savoure A., Jaoua S., Hua X.J., Ardiles W., van Montagu M., Verbruggen N.;
"Isolation, characterization, and chromosomal location of a gene encoding the delta 1-pyrroline-5-carboxylate synthetase in Arabidopsis thaliana.";
FEBS Lett. 372:13-19(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
DOI=10.1046/j.1365-313X.1997.00557.x; PubMed=9351242 [NCBI, ExPASy, EBI, Israel, Japan]
Strizhov N., Abraham E., Oekresz L., Blickling S., Zilberstein A., Schell J., Koncz C., Szabados L.;
"Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis.";
Plant J. 12:557-569(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
PubMed=7773306 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshiba Y., Kiyosue T., Katagiri T., Ueda H., Mizoguchi T., Yamaguchi-Shinozaki K., Wada K., Harada Y., Shinozaki K.;
"Correlation between the induction of a gene for delta 1-pyrroline-5-carboxylate synthetase and the accumulation of proline in Arabidopsis thaliana under osmotic stress.";
Plant J. 7:751-760(1995).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X89414; CAA61593.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X86777; CAA60446.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X87330; CAA60740.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D32138; BAA06864.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC003000; AAB87129.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF424633; AAL11626.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY113046; AAM47354.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY150430; AAN12972.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S66637; S66637.
T50685; T50685.
RefSeq NP_181510.1; -.
UniGene At.20482
3D structure databases
HSSP Q9WYC9; 1O20. [HSSP ENTRY / PDB]
ModBase P54887.
Organism-specific databases
TAIR At2g39800; -.
Gene expression databases
GermOnline AT2G39800; Arabidopsis thaliana.
Family and domain databases
InterPro IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR000965; Gglut_pp_reduct.
IPR001057; Glu_5kinase.
IPR005766; P5_carboxy_syn.
IPR005715; ProB.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
Pfam PF00696; AA_kinase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036429; P5C_syn; 1.
PRINTS PR00474; GLU5KINASE.
TIGRFAMs TIGR01092; P5CS; 1.
TIGR00407; proA; 1.
TIGR01027; proB; 1.
PROSITE PS00902; GLUTAMATE_5_KINASE; 1.
PS01223; PROA; 1.
BLOCKS P54887.
Genome annotation databases
GeneID 818566; -.
GenomeReviews CT485783_GR; AT2G39800.
KEGG ath:AT2G39800; -.
Other
ProtoNet P54887.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Amino-acid biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; NADP; Oxidoreductase; Proline biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   717  717     Delta-1-pyrroline-5-carboxylate synthetase A. PRO_0000109772
REGION   1   296  296     Glutamate 5-kinase. 
REGION   297   717  421     Gamma-glutamyl phosphate reductase. 
CONFLICT   42    42        C -> F (in Ref. 3; BAA06864). 
CONFLICT   54    54        E -> K (in Ref. 3; BAA06864). 
CONFLICT   381   381        D -> E (in Ref. 3; BAA06864). 
CONFLICT   467   467        L -> F (in Ref. 3; BAA06864). 
CONFLICT   676   676        H -> Y (in Ref. 3; BAA06864). 
Sequence information
Length: 717 AA [This is the length of the unprocessed precursor] Molecular weight: 77702 Da [This is the MW of the unprocessed precursor] CRC64: DF2B296362351A78 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEELDRSRAF ARDVKRIVVK VGTAVVTGKG GRLALGRLGA LCEQLAELNS DGFEVILVSS 

        70         80         90        100        110        120 
GAVGLGRQRL RYRQLVNSSF ADLQKPQTEL DGKACAGVGQ SSLMAYYETM FDQLDVTAAQ 

       130        140        150        160        170        180 
LLVNDSSFRD KDFRKQLNET VKSMLDLRVI PIFNENDAIS TRRAPYQDSS GIFWDNDSLA 

       190        200        210        220        230        240 
ALLALELKAD LLILLSDVEG LYTGPPSDPN SKLIHTFVKE KHQDEITFGD KSRLGRGGMT 

       250        260        270        280        290        300 
AKVKAAVNAA YAGIPVIITS GYSAENIDKV LRGLRVGTLF HQDARLWAPI TDSNARDMAV 

       310        320        330        340        350        360 
AARESSRKLQ ALSSEDRKKI LLDIADALEA NVTTIKAENE LDVASAQEAG LEESMVARLV 

       370        380        390        400        410        420 
MTPGKISSLA ASVRKLADME DPIGRVLKKT EVADGLVLEK TSSPLGVLLI VFESRPDALV 

       430        440        450        460        470        480 
QIASLAIRSG NGLLLKGGKE ARRSNAILHK VITDAIPETV GGKLIGLVTS REEIPDLLKL 

       490        500        510        520        530        540 
DDVIDLVIPR GSNKLVTQIK NTTKIPVLGH ADGICHVYVD KACDTDMAKR IVSDAKLDYP 

       550        560        570        580        590        600 
AACNAMETLL VHKDLEQNAV LNELIFALQS NGVTLYGGPR ASKILNIPEA RSFNHEYCAK 

       610        620        630        640        650        660 
ACTVEVVEDV YGAIDHIHRH GSAHTDCIVT EDHEVAELFL RQVDSAAVFH NASTRFSDGF 

       670        680        690        700        710 
RFGLGAEVGV STGRIHARGP VGVEGLLTTR WIMRGKGQVV DGDNGIVYTH QDIPIQA 

P54887 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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