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UniProtKB/Swiss-Prot entry P54875

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI_METTF
Primary accession number P54875
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name DNA ligase
Synonyms EC 6.5.1.1
Polydeoxyribonucleotide synthase [ATP]
Gene name
Name: lig
From
Methanobacterium thermoformicicum [TaxID: 145262] 
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DSM 3720 / Z-245;
PubMed=9006048 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Reeve J.N.;
"Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245.";
J. Bacteriol. 179:899-908(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U52681; AAC44823.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase P54875.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00407; -; 1.
PBIL [Tree]
InterPro IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet P54875.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   557  557     DNA ligase. PRO_0000059608
ACT_SITE   251   251        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 557 AA [This is the length of the unprocessed precursor] Molecular weight: 62822 Da [This is the MW of the unprocessed precursor] CRC64: C328FE239AD1CBAA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKELLYMELA EVYHRLESTT KRLEKTEILA ELLRSVDKEL LPDVTILMLG RVFPIWSEEE 

        70         80         90        100        110        120 
LGVGIKLLMK AISLVVGVSM DEIEDEIREQ GDIGLASEKL FSRKTQTTFF SQPLTVEFVY 

       130        140        150        160        170        180 
SRLKALASAS GDRAQSKKIN ILVEVLSQAK PLEARYITRT VLEELRVGVA EGIIRDAIAR 

       190        200        210        220        230        240 
AFEVDPALVE RAHMLTNDLG MVAAVAREEG EPGLGRLNLE PGRPVKPMLA QLASSIESAI 

       250        260        270        280        290        300 
TELGRAFCET KYDGIRVQIH RCGDEVSIFT RRLENITAAV PEILEGVEEA LPADDYIVEG 

       310        320        330        340        350        360 
EIIVTMDGRP ASFQYILQRV RRKYDVDRLT REVPLSLFLF DVLYHRGPLI DEPLWHRREV 

       370        380        390        400        410        420 
LESILSEIPG RVEASRMVDV GPDNLDDALW LFKESIREGH EGIMIKDTEA PYIPGIRGKK 

       430        440        450        460        470        480 
MLKFKAEPET LDLIVVGGTY GRGKRAHLVG SYLLAVRDEK SGELKTIAHV ATGLDDQTLQ 

       490        500        510        520        530        540 
DLSERMENLK VERRGRKIRV KPEIILEVAY SEIVRSPEYE SGYSLRFPVV KRIRDDLSPD 

       550 
DIDTLGRVIS LFKQGFS
P54875 in FASTA format

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