[1]	PROTEIN SEQUENCE. TISSUE=Heart; PubMed=9504812 [NCBI, ExPASy, EBI, Israel, Japan] Dunn M.J., Corbett J.M., Wheeler C.H.; "HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins."; Electrophoresis 18:2795-2802(1997).

Comments

CATALYTIC ACTIVITY: Isocitrate + NAD⁺ = 2-oxoglutarate + CO₂ + NADH.
SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases
ModBase	P54836.
2D gel databases
HSC-2DPAGE	P54836; -.
Family and domain databases
InterPro	IPR001804; IsoCit_IM_DHase. Graphical view of domain structure.
PROSITE	PS00470; IDH_IMDH; PARTIAL.
BLOCKS	P54836.
Phylogenomic databases
HOVERGEN	P54836; -.
Other
ProtoNet	P54836.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >13`	`>13`	`Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial.`	`PRO_0000083589`
`NON_TER`	`13 13`

Sequence information

Length: 13 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 1356 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 9ABFBC2B2A34B2D1 [This is a checksum on the sequence]

        10 
AIEVQTVTLI PGD

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools