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UniProtKB/Swiss-Prot entry P54388


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE4_LACBS
Primary accession number P54388
Secondary accession number B0CZ97
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on May 20, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name NADP-specific glutamate dehydrogenase
Synonyms NADP-GDH
EC 1.4.1.4
NADP-dependent glutamate dehydrogenase
Gene name
Name: GDHA
ORFNames: LACBIDRAFT_292653
From
Laccaria bicolor (strain S238N-H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) [TaxID: 486041] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; Agaricomycetidae; Agaricales; Tricholomataceae; Laccaria.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Lorillou S.S., Martin F.F.;
"Cloning, sequence analysis and expression of a cDNA encoding NADP-glutamate dehydrogenase from the ectomycorrhizal basidiomycete Laccaria bicolor.";
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature06556; PubMed=18322534 [NCBI, ExPASy, EBI, Israel, Japan]
Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D., Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.;
"The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis.";
Nature 452:88-92(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U31369; AAA82936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DS547094; EDR12114.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001876378.1; -.
3D structure databases
HSSP P24295; 1AUP. [HSSP ENTRY / PDB]
ModBase P54388.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004354; Molecular function: glutamate dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0006520; Biological process: amino acid metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
Genome annotation databases
GeneID 6072874; -.
KEGG lbc:LACBIDRAFT_292653; -.
Other
ProtoNet P54388.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   450  450     NADP-specific glutamate dehydrogenase. PRO_0000182789
ACT_SITE   111   111        By similarity. 
CONFLICT   17    17        Q -> P (in Ref. 1; AAA82936). 
CONFLICT   31    31        E -> G (in Ref. 1; AAA82936). 
CONFLICT   38    38        Q -> P (in Ref. 1; AAA82936). 
CONFLICT   49    49        V -> I (in Ref. 1; AAA82936). 
CONFLICT   231   231        A -> G (in Ref. 1; AAA82936). 
CONFLICT   349   349        A -> E (in Ref. 1; AAA82936). 
Sequence information
Length: 450 AA [This is the length of the unprocessed precursor] Molecular weight: 48550 Da [This is the MW of the unprocessed precursor] CRC64: 8FDA699CA3D46945 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVLPVEPEYE QALSELQNSL KPFLAANPDY EKALEIVQIP ERVLQFRVVW EDDQGKAQVN 

        70         80         90        100        110        120 
RGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN ALTGLSMGGG KGGSDFDPKG 

       130        140        150        160        170        180 
KSDGEIRRFC TSFMSELFRH IGQDTDVPAG DIGTGAREIG YLFGAYKKLQ NEFVGMLTGK 

       190        200        210        220        230        240 
GLAWGGSFIR PEATGYGLIY YVEHMIAKAA PEYSLSKPET LVAISGSGNV AQFTALKVIE 

       250        260        270        280        290        300 
LGATVLSLSD SKGSLIAEKG YTKEFIKEIG QLKLKGGALE SLAQREGYTY HAGKRPWSLL 

       310        320        330        340        350        360 
PVVHVALPGA TQNEVSKTEA EDLIKAGVRI VAEGSNMGCT EDAIAVFEAS RKAGAGGVWY 

       370        380        390        400        410        420 
APGKASNCGG VAVSGLEMAQ NSQRLAWTTD QVDQKLKKIM AECYEICLSA GTKWSGEEIK 

       430        440        450 
DGVLPSLLSG ANVAGFIKVA DAMREHGDWW 

P54388 in FASTA format

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