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UniProtKB/Swiss-Prot entry P54270

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3PC_GRAVE
Primary accession number P54270
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
Synonym EC 1.2.1.12
Gene name
Name: GAPC
From
Gracilaria verrucosa (Red alga) [TaxID: 2777] 
Taxonomy Eukaryota; Rhodophyta; Florideophyceae; Gracilariales; Gracilariaceae; Gracilaria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/BF00326430; PubMed=8590478 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou Y.H., Ragan M.A.;
"The nuclear gene and cDNAs encoding cytosolic glyceraldehyde-3-phosphate dehydrogenase from the marine red alga Gracilaria verrucosa: cloning, characterization and phylogenetic analysis.";
Curr. Genet. 28:324-332(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L38661; AAB01379.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S59579; S59579.
3D structure databases
HSSP P56649; 1DSS. [HSSP ENTRY / PDB]
SMR P54270; 5-334.
ModBase P54270.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006424; Glyceraldehyde-3-P_DHase_1.
Graphical view of domain structure.
PANTHER PTHR10836; GAP_DH; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
PRINTS PR00078; G3PDHDRGNASE.
TIGRFAMs TIGR01534; GAPDH-I; 1.
PROSITE PS00071; GAPDH; 1.
Other
ProtoNet P54270.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Glyceraldehyde-3-phosphate dehydrogenase, cytosolic. PRO_0000145601
NP_BIND   13    14  2     NAD (By similarity). 
REGION   151   153  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   211   212  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   152   152        Nucleophile (By similarity). 
BINDING   35    35        NAD (By similarity). 
BINDING   80    80        NAD; via carbonyl oxygen (By similarity). 
BINDING   182   182        Glyceraldehyde 3-phosphate (By similarity). 
BINDING   234   234        Glyceraldehyde 3-phosphate (By similarity). 
BINDING   316   316        NAD (By similarity). 
SITE   179   179  1     Activates thiol group during catalysis (By similarity). 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 36144 Da [This is the MW of the unprocessed precursor] CRC64: 5B97F5BF3D40ACB0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVPQVGING FGRIGRLVLR AAIEKDTMSV VAINDPFIDL EYMAYMFKFD STHGRYAGSV 

        70         80         90        100        110        120 
ETKDGKLIVN GKSITIYGHR DPAEIPWAEA GADYVVESTG VFTLKEKAEK HFTGGAKKVI 

       130        140        150        160        170        180 
ISAPSKDAPM FVCGVNEDKY TPDLNVISNA SCTTNCLAPL VKVIHEKYGI EEGLMTTVHA 

       190        200        210        220        230        240 
TTATQKTVDG PSQKDWRGGR GAGANIIPSS TGAAKAVGKV LPELNGKLTG MAFRVPTSDV 

       250        260        270        280        290        300 
SVVDLTVRLA TETSYDDIKA TMKAAAEDSM KGILKYTEEA VVSTDFIHEE ASCVFDAGAG 

       310        320        330 
IMLNSRFCKL VAWYDNEWGY SNRVVDLIAH VAKLQ
P54270 in FASTA format

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