[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Bone marrow; DOI=10.1074/jbc.271.45.28375; PubMed=8910461 [NCBI, ExPASy, EBI, Israel, Japan] Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A., Zanetti M.; "Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities."; J. Biol. Chem. 271:28375-28381(1996).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Thymus; NIH - Mammalian Gene Collection (MGC) project; Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
[3]	CHARACTERIZATION, AND MASS SPECTROMETRY. PubMed=8706679 [NCBI, ExPASy, EBI, Israel, Japan] Storici P., Tossi A., Lenarcic B., Romeo D.; "Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides."; Eur. J. Biochem. 238:769-776(1996).

Comments

FUNCTION: Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.
SUBCELLULAR LOCATION: Secreted.
MASS SPECTROMETRY: Mass=14414; Mass_error=1; Method=Electrospray; Range=30-159; Source=PubMed:8706679;.
SIMILARITY: Belongs to the cathelicidin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X97609; CAA66208.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC142015; AAI42016.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_776935.1; -.

UniGene

Bt.15991

3D structure databases

HSSP

P32196; 1KWI. [HSSP ENTRY / PDB]

SMR

P54229; 30-131.

ModBase

P54229.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001894; Cathelicidin.
Graphical view of domain structure.

PANTHER

PTHR10206; Cathelicidin; 1.

Pfam

PF00666; Cathelicidins; 1.
Pfam graphical view of domain structure.

ProDom

PD001838; Cathelicidin; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00946; CATHELICIDINS_1; 1.
PS00947; CATHELICIDINS_2; 1.

Genome annotation databases

Ensembl

ENSBTAG00000020076; Bos taurus. [Contig view]

GeneID

282167; -.

KEGG

bta:282167; -.

Phylogenomic databases

HOVERGEN

P54229; -.

Other

ProtoNet

P54229.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Pyrrolidone carboxylic acid; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 29`	`29`	`Potential.`
`PROPEP`	`30 131`	`102`		`PRO_0000004716`
`PEPTIDE`	`132 159`	`28`	`Cathelicidin-5.`	`PRO_0000004717`
`MOD_RES`	`30 30`		`Pyrrolidone carboxylic acid.`
`DISULFID`	`86 97`		`By similarity.`
`DISULFID`	`108 125`		`By similarity.`

Sequence information

Length: 159 AA [This is the length of the unprocessed precursor]

Molecular weight: 17616 Da [This is the MW of the unprocessed precursor]

CRC64: 89B7CB46C5EEC367 [This is a checksum on the sequence]

        10         20         30         40         50         60 
METQRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQLNEKSS EANLYRLLEL 

        70         80         90        100        110        120 
DPPPKEDDEN PNIPKPVSFR VKETVCPRTS QQSPEQCDFK ENGLLKECVG TVTLDQVGSN 

       130        140        150 
FDITCAVPQS VGGLRSLGRK ILRAWKKYGP IIVPIIRIG

P54229 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools