ID   BETB1_RHIME             Reviewed;         487 AA.
AC   P54222;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   04-NOV-2008, entry version 56.
DE   RecName: Full=Betaine aldehyde dehydrogenase 1;
DE            Short=BADH 1;
DE            EC=1.2.1.8;
GN   Name=betB1; Synonyms=betB; OrderedLocusNames=R00948;
GN   ORFNames=SMc00094;
OS   Rhizobium meliloti (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=102F34;
RX   MEDLINE=97286552; PubMed=9141699;
RA   Pocard J.A., Vincent N., Boncompagni E., Tombras Smith L.,
RA   Poggi M.-C., Le Rudulier D.;
RT   "Molecular characterization of the bet genes encoding glycine betaine
RT   synthesis in Sinorhizobium meliloti 102F34.";
RL   Microbiology 143:1369-1379(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA   Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA   Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont
RT   Sinorhizobium meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; U39940; AAC13368.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC45520.1; -; Genomic_DNA.
DR   RefSeq; NP_385054.1; -.
DR   HSSP; P56533; 1A4S.
DR   GeneID; 1232591; -.
DR   GenomeReviews; AL591688_GR; R00948.
DR   KEGG; sme:SMc00094; -.
DR   NMPDR; fig|266834.1.peg.2242; -.
DR   HOGENOM; P54222; -.
DR   BioCyc; MetaCyc:MON-246; -.
DR   BioCyc; SMEL266834:SMC00094-MON; -.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR011264; Betaine_Ald_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       Betaine aldehyde dehydrogenase 1.
FT                                /FTId=PRO_0000056553.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    250    250       By similarity.
FT   ACT_SITE    284    284       By similarity.
FT   CONFLICT     82     82       R -> L (in Ref. 1; AAC13368).
FT   CONFLICT    374    374       V -> D (in Ref. 1; AAC13368).
SQ   SEQUENCE   487 AA;  51549 MW;  D548CDF0BB1329AA CRC64;
     MRAQPKASHF IDGEYVEDAA GTVIESIYPA TGEIIARLHA ATPGIVEKAI AAAKRAQPEW
     AAMSPTARGR ILKRAAELMR QRNRELSELE TLDTGKPIQE TIVADPTSGA DSFEFFGGVA
     PAALNGDYIP LGGDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALVAG NAMVFKPSEN
     TPLGALKIAE ILIEAGLPKG LFNVIQGDRA TGPLLVNHPD VAKVSLTGSV PTGKKVAGAA
     AAELKHVTME LGGKSPLIVF DDADLESAIG GAMLGNFYST GQVCSNGTRV FVQRKIKEPF
     LARLKERTEA IVIGDPLDEA TQLGPMVSAA QRDKVFSYIG KGKAEGARLV TGGGIPNNVS
     GEGTYIQPTV FADVTDGMTI AREEIFGPVM CVLDFDDEVE VIARANATEF GLSAGVFTAD
     LTRAHRVADR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSVAALNHY TELKTVYVGM
     GPVEAPY
//