NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=102F34;
PubMed=9141699 [NCBI, ExPASy, EBI, Israel, Japan]
Pocard J.A., Vincent N., Boncompagni E., Tombras Smith L., Poggi M.-C., Le Rudulier D.;
"Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34.";
Microbiology 143:1369-1379(1997).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1021;
DOI=10.1073/pnas.161294398; PubMed=11481430 [NCBI, ExPASy, EBI, Israel, Japan]
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.";
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).

Comments

CATALYTIC ACTIVITY: Betaine aldehyde + NAD⁺ + H₂O = betaine + NADH.
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U39940; AAC13368.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591688; CAC45520.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_385054.1; -.

3D structure databases

HSSP

P56533; 1A4S. [HSSP ENTRY / PDB]

ModBase

P54222.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-246; -.
SMEL266834:SMC00094-MON; -.

Ontologies

GO:0008802;	Molecular function: betaine-aldehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00804; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR011264; Betaine_Ald_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01804; BADH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

P54222.

Genome annotation databases

1232591; -.

AL591688_GR; R00948.

sme:SMc00094; -.

fig|266834.1.peg.2242; -.

Phylogenomic databases

HOGENOM

P54222; -.

Genome annotation databases

CMR

P54222; R00948.

Other

ProtoNet

P54222.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 487`	`487`	`Betaine aldehyde dehydrogenase 1.`	`PRO_0000056553`
`NP_BIND`	`228 233`	`6`	`NAD (By similarity).`
`ACT_SITE`	`250 250`		`By similarity.`
`ACT_SITE`	`284 284`		`By similarity.`
`CONFLICT`	`82 82`		`R -> L (in Ref. 1; AAC13368).`
`CONFLICT`	`374 374`		`V -> D (in Ref. 1; AAC13368).`

Sequence information

Length: 487 AA [This is the length of the unprocessed precursor]

Molecular weight: 51549 Da [This is the MW of the unprocessed precursor]

CRC64: D548CDF0BB1329AA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRAQPKASHF IDGEYVEDAA GTVIESIYPA TGEIIARLHA ATPGIVEKAI AAAKRAQPEW 

        70         80         90        100        110        120 
AAMSPTARGR ILKRAAELMR QRNRELSELE TLDTGKPIQE TIVADPTSGA DSFEFFGGVA 

       130        140        150        160        170        180 
PAALNGDYIP LGGDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALVAG NAMVFKPSEN 

       190        200        210        220        230        240 
TPLGALKIAE ILIEAGLPKG LFNVIQGDRA TGPLLVNHPD VAKVSLTGSV PTGKKVAGAA 

       250        260        270        280        290        300 
AAELKHVTME LGGKSPLIVF DDADLESAIG GAMLGNFYST GQVCSNGTRV FVQRKIKEPF 

       310        320        330        340        350        360 
LARLKERTEA IVIGDPLDEA TQLGPMVSAA QRDKVFSYIG KGKAEGARLV TGGGIPNNVS 

       370        380        390        400        410        420 
GEGTYIQPTV FADVTDGMTI AREEIFGPVM CVLDFDDEVE VIARANATEF GLSAGVFTAD 

       430        440        450        460        470        480 
LTRAHRVADR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSVAALNHY TELKTVYVGM 


GPVEAPY

P54222 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools