NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/s002940050026; PubMed=8821658 [NCBI, ExPASy, EBI, Israel, Japan]
Hunter G.D., Jones I.G., Sealy-Lewis H.M.;
"The cloning and sequencing of the alcB gene, coding for alcohol dehydrogenase II, in Aspergillus nidulans.";
Curr. Genet. 29:122-129(1996).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC 4;
DOI=10.1038/nature04341; PubMed=16372000 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z48000; CAA88034.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AACD01000061; EAA59949.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S62746; S62746.

RefSeq

XP_661345.1; -.

3D structure databases

HSSP

P39462; 1JVB. [HSSP ENTRY / PDB]

ModBase

P54202.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

BLOCKS

P54202.

Genome annotation databases

GeneID

2873163; -.

KEGG

ani:AN3741.2; -.

Other

ProtoNet

P54202.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 367`	`367`	`Alcohol dehydrogenase 2.`	`PRO_0000160720`
`METAL`	`48 48`		`Zinc 1; catalytic (By similarity).`
`METAL`	`74 74`		`Zinc 1; catalytic (By similarity).`
`METAL`	`107 107`		`Zinc 2 (By similarity).`
`METAL`	`110 110`		`Zinc 2 (By similarity).`
`METAL`	`113 113`		`Zinc 2 (By similarity).`
`METAL`	`121 121`		`Zinc 2 (By similarity).`
`METAL`	`163 163`		`Zinc 1; catalytic (By similarity).`
`CONFLICT`	`295 295`		`A -> R (in Ref. 1; CAA88034).`

Sequence information

Length: 367 AA [This is the length of the unprocessed precursor]

Molecular weight: 38690 Da [This is the MW of the unprocessed precursor]

CRC64: 0B65AC6CD0306663 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAPEIPKKQ KAVIYDNPGT VSTKVVELDV PEPGDNEVLI NLTHSGVCHS DFGIMTNTWK 

        70         80         90        100        110        120 
ILPFPTQPGQ VGGHEGVGKV VKLGAGAEAS GLKIGDRVGV KWISSACGQC PPCQDGADGL 

       130        140        150        160        170        180 
CFNQKVSGYY TPGTFQQYVL GPAQYVTPIP DGLPSAEAAP LLCAGVTVYA SLKRSKAQPG 

       190        200        210        220        230        240 
QWIVISGAGG GLGHLAVQIA AKGMGLRVIG VDHGSKEELV KASGAEHFVD ITKFPTGDKF 

       250        260        270        280        290        300 
EAISSHVKSL TTKGLGAHAV IVCTASNIAY AQSLLFLRYN GTMVCVGIPE NEPQAIASAY 

       310        320        330        340        350        360 
PGLFIQKHVH VTGSAVGNRN EAIETMEFAA RGVIKAHFRE EKMEALTEIF KEMEEGKLQG 


RVVLDLS

P54202 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools