ID   MSRA_BRANA              Reviewed;         257 AA.
AC   P54151;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 39.
DE   RecName: Full=Peptide methionine sulfoxide reductase;
DE            EC=1.8.4.11;
DE   AltName: Full=Protein-methionine-S-oxide reductase;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE            Short=Peptide Met(O) reductase;
GN   Name=PMSR;
OS   Brassica napus (Rape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Brassica.
OX   NCBI_TaxID=3708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. Jet neuf;
RX   PubMed=8111035; DOI=10.1007/BF00020171;
RA   Keddie J.S., Tsiantis M., Piffanelli P., Cella R., Hatzopoulos P.,
RA   Murphy D.J.;
RT   "A seed-specific Brassica napus oleosin promoter interacts with a G-
RT   box-specific protein and may be bi-directional.";
RL   Plant Mol. Biol. 24:327-340(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS LEU-4; ALA-14; SER-24; ALA-75
RP   AND SER-129.
RC   TISSUE=Leaf;
RX   MEDLINE=96367667; PubMed=8771781;
RA   Sadanandom A.C., Piffanelli P., Knott T., Robinson C., Sharpe A.,
RA   Lydiate D., Murphy D.J., Fairbairn D.J.;
RT   "Identification of a peptide methionine sulphoxide reductase gene in
RT   an oleosin promoter from Brassica napus.";
RL   Plant J. 10:235-242(1996).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine.
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
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DR   EMBL; X94225; CAA63919.1; -; Genomic_DNA.
DR   EMBL; Z48619; CAA88538.1; -; mRNA.
DR   EMBL; X91486; CAA62760.1; -; mRNA.
DR   PIR; S55365; S55365.
DR   PIR; T47215; T47215.
DR   HSSP; P27110; 1FF3.
DR   SMR; P54151; 77-257.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0019538; P:protein metabolic process; IEA:InterPro.
DR   InterPro; IPR002569; MsrA.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   ProDom; PD003489; PMSR; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Polymorphism.
FT   CHAIN         1    257       Peptide methionine sulfoxide reductase.
FT                                /FTId=PRO_0000138633.
FT   VARIANT       4      4       I -> L.
FT   VARIANT      14     14       V -> A.
FT   VARIANT      24     24       A -> S.
FT   VARIANT      75     75       S -> A.
FT   VARIANT     129    129       T -> S.
SQ   SEQUENCE   257 AA;  28466 MW;  41F4440E41772788 CRC64;
     MLSIVASPPV ISAVSLSKPL QSLAKAALSL SKRAKPTSPF PKTARSISVY KSPMNNLFTR
     LGFGSRPQPD PAASSAIAQG PDDDVPSPGQ QFAQFGAGCF WGAELAYQRV PGVTKTEVGY
     SHGFVDNPTY EDVCSETTGH NEIVRVQYDP KEVSFESLLD VFWKRHDPTT LNRQGNDVGT
     RYRSGIYFYT DEQEKLAREA MEKQQKILNR KIVTEILPAT KFYRAENYHQ QYLAKGGRMG
     LSQSAEKGCN DPIRCYG
//